Tremor is associated with familial clustering of dystonia

Dystonia is a movement disorder of variable etiology and clinical presentation and is accompanied by tremor in about 50% of cases. Monogenic causes in dystonia are rare, but also in the group of non-monogenic dystonias 10–30% of patients report a family history of dystonia. This points to a number o...

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Published in:Parkinsonism & related disorders 2023-05, Vol.110, p.105400-105400, Article 105400
Main Authors: Loens, Sebastian, Hamami, Feline, Lohmann, Katja, Odorfer, Thorsten, Ip, Chi Wang, Zittel, Simone, Zeuner, Kirsten E., Everding, Judith, Becktepe, Jos, Marth, Katrin, Borngräber, Friederike, Kollewe, Katja, Kamm, Christoph, Kühn, Andrea A., Gelderblom, Mathias, Volkmann, Jens, Klein, Christine, Bäumer, Tobias
Format: Article
Language:English
Subjects:
Cluster Analysis
Dystonia - etiology
Dystonic Disorders - complications
Dystonic Disorders - epidemiology
Dystonic Disorders - genetics
Humans
Movement Disorders - complications
Tremor - complications
Tremor - epidemiology
Tremor - genetics
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Summary:Dystonia is a movement disorder of variable etiology and clinical presentation and is accompanied by tremor in about 50% of cases. Monogenic causes in dystonia are rare, but also in the group of non-monogenic dystonias 10–30% of patients report a family history of dystonia. This points to a number of patients currently classified as idiopathic that have at least in part an underlying genetic contribution. The present study aims to identify clinical and demographic features associated with heritability of yet idiopathic dystonia. Seven hundred thirty-three datasets were obtained from the DysTract dystonia registry, patients with acquired dystonia or monogenic causes were excluded. Affected individuals were assigned to a familial and sporadic group, and clinical features were compared across these groups. Additionally, the history of movement disorders was also counted in family members. 18.2% of patients reported a family history of dystonia. Groups differed in age at onset, disease duration and presence of tremor on a descriptive level. Logistic regression analysis revealed that tremor was the only predictor for a positive family history of dystonia (OR 2.49, CI = 1.54–4.11, p 
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2023.105400