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Combination therapy as a first step of treatment in diabetes: Changing the paradigm in KDIGO guidelines?

•New KDIGO guidelines for diabetes mellitus treatment in chronic kidney disease suggest to early start treatment with a drug combination (metformin plus SGLT2i).•Although there is no available on the use of this combination from the beginning there is enough background of safety and efficacy to supp...

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Bibliographic Details
Published in:European journal of internal medicine 2023-05, Vol.111, p.21-23
Main Authors: Robles, Nicolás Roberto, Alvarez, Alvaro, Fici, Francesco
Format: Article
Language:English
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Summary:•New KDIGO guidelines for diabetes mellitus treatment in chronic kidney disease suggest to early start treatment with a drug combination (metformin plus SGLT2i).•Although there is no available on the use of this combination from the beginning there is enough background of safety and efficacy to support this use.•This is an important, although expected, change in the current recommendations of type 2 diabetes mellitus treatment. Nevertheless, it is restricted to chronic kidney disease patients.
ISSN:0953-6205
1879-0828
DOI:10.1016/j.ejim.2023.02.024