Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer

• Published in: International journal of biological macromolecules 2023-06, Vol.241, p.124508-124508, Article 124508
• Main Authors: Hassani, Sepideh, Maghsoudi, Hossein, Fattahi, Fahimeh, Malekinejad, Faezeh, Hajmalek, Nooshin, Sheikhnia, Farhad, Kheradmand, Fatemeh, Fahimirad, Shohreh, Ghorbanpour, Mansour
• Format: Article
• Language: English
• Subjects: Colorectal cancer; Colorectal Neoplasms - drug therapy; Flavonoid; Flavonoids - chemistry; Flavonoids - pharmacology; Flavonoids - therapeutic use; Humans; Nano-formulation; Nanoparticles - chemistry; Polyphenol; Polyphenols - chemistry; Polyphenols - pharmacology; Polyphenols - therapeutic use; Quercetin - chemistry
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2023.124508

Colorectal cancer is among the frequently diagnosed cancers with high mortality rates around the world. Polyphenolic compounds such as flavonoids are secondary plant metabolites which exhibit anti-cancer activities along with anti-inflammatory effects. However, due to their hydrophobicity, sensitivity to degradation and low bioavailability, therapeutic effects have shown poor therapeutic effect. Nano delivery systems such as nanoliposomes, nanomicelles, silica nanoparticles have been investigated to overcome these difficulties. This review provides a summary of the efficiency of certain flavonoids and polyphenols (apigenin, genistein, resveratrol, quercetin, silymarin, catechins, luteolin, fisetin, gallic acid, rutin, and curcumin) on colorectal cancer models. It comprehensively discusses the influence of nano-formulation of flavonoids on their biological functions, including cellular uptake rate, bioavailability, solubility, and cytotoxicity, as well as their potential for reducing colorectal cancer tumor size under in vivo situations. •Colorectal cancer is considered as one of the worldwide frequent diagnosed cancers with high mortality.•Flavonoids are secondary plant metabolites efficiently have exerted significant anti- colorectal cancer impacts.•Poor water solubility, degradation sensitivity and weak bioavailability hinder the board clinical application of flavonoids.•Different nanotechnology based formulations have overcome difficulties faced on flavonoids deliveries.•Flavonoids various nano-formulation have introduced novel approach for targeted delivery of desired flavonoids to tumor site.