Computational modeling of the human compound action potential

The auditory nerve (AN) compound action potential (CAP) is an important tool for assessing auditory disorders and monitoring the health of the auditory periphery during surgical procedures. The CAP has been mathematically conceptualized as the convolution of a unit response (UR) waveform with the fi...

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Bibliographic Details
Published in:The Journal of the Acoustical Society of America 2023-04, Vol.153 (4), p.2376-2376
Main Authors: Alamri, Yousef, Jennings, Skyler G
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Action Potentials - physiology
Auditory Threshold - physiology
Cochlea
Cochlear Nerve
Computer Simulation
Hearing Loss
Humans
Noise
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Summary:The auditory nerve (AN) compound action potential (CAP) is an important tool for assessing auditory disorders and monitoring the health of the auditory periphery during surgical procedures. The CAP has been mathematically conceptualized as the convolution of a unit response (UR) waveform with the firing rate of a population of AN fibers. Here, an approach for predicting experimentally recorded CAPs in humans is proposed, which involves the use of human-based computational models to simulate AN activity. CAPs elicited by clicks, chirps, and amplitude-modulated carriers were simulated and compared with empirically recorded CAPs from human subjects. In addition, narrowband CAPs derived from noise-masked clicks and tone bursts were simulated. Many morphological, temporal, and spectral aspects of human CAPs were captured by the simulations for all stimuli tested. These findings support the use of model simulations of the human CAP to refine existing human-based models of the auditory periphery, aid in the design and analysis of auditory experiments, and predict the effects of hearing loss, synaptopathy, and other auditory disorders on the human CAP.
ISSN:0001-4966
1520-8524
DOI:10.1121/10.0017863