The Evaluation of Intestinal Permeability in Preeclamptic Pregnancy

Zonulin is a physiological protein that regulates the tight connections and permeability of the intestine, serving as a biomarker for impaired intestinal permeability. The aim of this study was to examine zonulin levels in preeclampsia, to investigate its associations with the cellular immune respon...

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Bibliographic Details
Published in:Materia socio-medica 2023-03, Vol.35 (1), p.48-52
Main Authors: Mutluoglu, Gulsen, Yay, Tugba, Gülsever, Aycan Bölük, Madenci, Özlem Cakir, Kaptanagasi, Asuman Orcun
Format: Article
Language:English
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Summary:Zonulin is a physiological protein that regulates the tight connections and permeability of the intestine, serving as a biomarker for impaired intestinal permeability. The aim of this study was to examine zonulin levels in preeclampsia, to investigate its associations with the cellular immune response marker soluble interleukin-2 receptor (sIL-2R) and exogenous antigen load marker lipopolysaccharide binding protein (LBP) and to evaluate the implications of these findings in the etiopathogenesis of preeclampsia. We designed a cross-sectional case-control study and enrolled 22 pregnant women with preeclampsia and 22 healthy pregnant controls. Plasma zonulin levels were determined by ELISA. Serum sIL-2R and LBP levels were assessed by chemiluminescent immunometric methods. Women with preeclampsia had lower levels of plasma zonulin and serum LBP than normotensive healthy controls (p
ISSN:1512-7680
DOI:10.5455/msm.2023.35.48-52