Prospective Study of a Modified Post-Transplantation Cyclophosphamide Regimen for Severe Aplastic Anemia Patients with HLA-Haploidentical Transplantation

•Bone marrow plus peripheral blood stem cell grafts in the post-transplantation cyclophosphamide (PTCy) regimen contributed to high and faster engraftment.•Adjusting the dose and timing of antithymocyte globulin in the PTCy regimen reduced the incidence of graft-versus-host disease.•Patients without...

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Published in:Transplantation and cellular therapy 2023-07, Vol.29 (7), p.463.e1-463.e7
Main Authors: Wu, Liangliang, Zhou, Ming, Li, Yumiao, Chen, Xiaowei, Mo, Wenjian, Wang, Caixia, Xu, Shilin, Zhou, Wei, Deng, Tingfen, Zhou, Ruiqing, Pan, Shiyi, Wang, Shunqing, Zhang, Yuping
Format: Article
Language:English
Subjects:
Anemia, Aplastic - therapy
Antilymphocyte Serum - therapeutic use
Bronchiolitis Obliterans Syndrome
Cyclophosphamide - therapeutic use
Engraftment
Graft vs Host Disease - drug therapy
Graft vs Host Disease - etiology
Graft vs Host Disease - prevention & control
GVHD
Hematopoietic Stem Cell Transplantation - methods
HLA-haploidentical HSCT
Humans
Prospective Studies
Severe aplastic anemia
Transplantation, Haploidentical
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Summary:•Bone marrow plus peripheral blood stem cell grafts in the post-transplantation cyclophosphamide (PTCy) regimen contributed to high and faster engraftment.•Adjusting the dose and timing of antithymocyte globulin in the PTCy regimen reduced the incidence of graft-versus-host disease.•Patients without fertility needs or with a ≥ 1-year disease course received PTCy plus busulfan.•Patients with fertility needs or a
ISSN:2666-6367
2666-6367
DOI:10.1016/j.jtct.2023.04.015