Increased plasma levels of non-sugar sweeteners in patients with symptomatic carotid atherosclerosis

Purpose. The non-sugar sweeteners acesulfame K and saccharin are considered safe, but there is conflicting evidence on their effects on cardiovascular health. Materials and methods. In this explorative pilot study, we measured plasma levels of acesulfame K and saccharin in 15 patients with symptomat...

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Published in:Scandinavian cardiovascular journal : SCJ 2023-12, Vol.57 (1), p.2205068-2205068
Main Authors: Stø, Kristine, Skagen, Karolina R., Valeur, Jørgen, Yang, Kuan, Bjerkeli, Vigdis, Aukrust, Pål, Skjelland, Mona, Halvorsen, Bente
Format: Article
Language:English
Subjects:
acesulfame K
Carotid Artery Diseases - diagnostic imaging
carotid atherosclerosis
Humans
ischemic stroke
microbiota
Non-sugar sweeteners
Pilot Projects
Saccharin
Sweetening Agents - adverse effects
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Summary:Purpose. The non-sugar sweeteners acesulfame K and saccharin are considered safe, but there is conflicting evidence on their effects on cardiovascular health. Materials and methods. In this explorative pilot study, we measured plasma levels of acesulfame K and saccharin in 15 patients with symptomatic carotid atherosclerosis, 18 asymptomatic patients and 15 control subjects. Fecal microbiota and short-chain fatty acids were analyzed. Dietary and medical history was assessed. Results. Symptomatic patients had higher levels of acesulfame K and saccharin compared to controls. Acesulfame K was associated with increased leukocyte count. Saccharin was associated with more severe carotid stenosis, as well as lower fecal butyric acid.
ISSN:1401-7431
1651-2006
DOI:10.1080/14017431.2023.2205068