A Cohort Study on the Effects of Maternal High Serum Iodine Status During Pregnancy on Infants in Terms of Iodine Status and Intellectual, Motor, and Physical Development

• Published in: Biological trace element research 2024, Vol.202 (1), p.133-144
• Main Authors: Wang, Sihan, Bu, Ye, Shao, Qingliang, Cai, Yan, Sun, Dianjun, Fan, Lijun
• Format: Article
• Language: English
• Subjects: Age; Biochemistry; Biomedical and Life Sciences; Biotechnology; Blood; Body Mass Index; Body size; Body weight; Cohort analysis; Cohort Studies; Cohorts; Engines; Female; Humans; Infant; Infant, Newborn; Infants; Iodine; Iodine - urine; Life Sciences; Nutrition; Nutritional Status; Oncology; Pregnancy; Serum; Surveys and Questionnaires; Weight
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-023-03677-1

The objective of the present study was to explore the effects of maternal iodine excess during pregnancy on infants’ neurodevelopment and physical development. A total of 143 mother–child pairs were enrolled in this cohort study. Maternal blood samples were collected during the obstetric examination. A mother–child questionnaire survey was conducted, and infants’ blood samples were collected during the newborn physical examination. Infants’ single-spot urine samples were collected, and intellectual, motor, and physical development were assessed at 2 months of age. The median (IQR) maternal serum iodine concentrations (SICs) in the first, second, and third trimesters of pregnancy were 91.2 (74.4, 102.2) μg/L, 81.2 (70.6, 94.8) μg/L, and 82.0 (68.9, 100.3) μg/L, respectively. In the first trimester of pregnancy, infants’ psychomotor developmental index (PDI), body mass index (BMI) and weight-for-length Z score (WLZ) were higher with maternal suitable SIC (40 ~ 92 μg/L) than with maternal excess SIC ( P