Cross-sectional and longitudinal relationships between ozone exposure and glucose homeostasis: Exploring the role of systemic inflammation and oxidative stress in a general Chinese urban population

• Published in: Environmental pollution (1987) 2023-07, Vol.329, p.121711-121711, Article 121711
• Main Authors: Tan, Qiyou, Wang, Bin, Ye, Zi, Mu, Ge, Liu, Wei, Nie, Xiuquan, Yu, Linling, Zhou, Min, Chen, Weihong
• Format: Article
• Language: English
• Subjects: Air pollution; Biomarkers; Cross-Sectional Studies; Diabetes risk; East Asian People; Glucose; Glucose homeostasis; Homeostasis; Humans; Inflammation - chemically induced; Inflammation - epidemiology; Insulin Resistance - genetics; Oxidative Stress; Ozone - toxicity; Systemic inflammation; Urban Population
• ISSN: 0269-7491; 1873-6424
• DOI: 10.1016/j.envpol.2023.121711

The adverse health effects of ozone pollution have been a globally concerned public health issue. Herein we aim to investigate the association between ozone exposure and glucose homeostasis, and to explore the potential role of systemic inflammation and oxidative stress in this association. A total of 6578 observations from the Wuhan-Zhuhai cohort (baseline and two follow-ups) were included in this study. Fasting plasma glucose (FPG) and insulin (FPI), plasma C-reactive protein (CRP, biomarker for systemic inflammation), urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG, biomarker for oxidative DNA damage), and urinary 8-isoprostane (biomarker for lipid peroxidation) were repeatedly measured. After adjusting for potential confounders, ozone exposure was positively associated with FPG, FPI, and homeostasis model assessment of insulin resistance (HOMA-IR), and negatively associated with HOMA of beta cell function (HOMA-β) in cross-sectional analyses. Each 10 ppb increase in cumulative 7-days moving average ozone was associated with a 13.19%, 8.31%, and 12.77% increase in FPG, FPI, and HOMA-IR, respectively, whereas a 6.63% decrease in HOMA-β (all P