Association of Bun/Cr ratio-based dehydration status with infarct volumes and stroke severity in acute ischemic stroke

Only a few clinical research had previously investigated the dehydration status to predict the evolution of the ischemic core. The aim of this study is to clarify the association between blood urea nitrogen (BUN)/creatinine (Cr)ratio-based dehydration and infarct volume measured using DWI (Diffusion...

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Published in:Clinical neurology and neurosurgery 2023-06, Vol.229, p.107741-107741, Article 107741
Main Authors: Li, Huanyin, Wang, Hao, Fu, Qingyin, Liu, Yang, Song, Bin, zhao, Jing, Lin, Jixian
Format: Article
Language:English
Subjects:
Acute ischemic stroke
Blood Urea Nitrogen
Body mass index
Brain Ischemia - complications
Brain Ischemia - diagnostic imaging
Cardiovascular disease
Creatinine
Dehydration
Dehydration - complications
Dehydration - diagnostic imaging
Diffusion Magnetic Resonance Imaging - methods
DWI
Humans
Hydration
Infarction - complications
Ischemia
Ischemic Stroke - complications
Laboratories
Magnetic resonance imaging
Neurology
NIHSS
Nitrogen
Patients
Regression analysis
Retrospective Studies
Risk factors
Severity of Illness Index
Statistical analysis
Stroke
Stroke - complications
Stroke severity
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Summary:Only a few clinical research had previously investigated the dehydration status to predict the evolution of the ischemic core. The aim of this study is to clarify the association between blood urea nitrogen (BUN)/creatinine (Cr)ratio-based dehydration and infarct volume measured using DWI (Diffusion-weighted imaging) at admission in patients with AIS (Acute Ischemic Stroke). We retrospectively recruited a total of 203 consecutive patients who were hospitalized through emergency or outpatient services within 72 h of acute ischemic stroke onset between October 2015 and September 2019. Stroke severity was measured by assessing the National Institutes of Health Stroke Scale (NIHSS) on admission. Infarct volume was measured using DWI with MATLAB software. In this study, 203 patients who met the study criteria were enrolled. Patients in the dehydration group (Bun/Cr ratio>15) had a higher median NIHSS score (6(IQR:4–10) VS. 5(3−7); P = 0.0015)and larger DWI infarct volume (1.55 ml (IQR:0.51–6.79) VS. (0.37 ml (0.05–1.22); P 
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2023.107741