Predictive accuracy of histopathological profile and immunohistochemical markers for the aging of abrasion: an autopsy-based study

Wound age estimation is a crucial medicolegal task for forensic pathologists. The main objective of the current study was to evaluate the ability of the histopathological profile and immunohistochemical markers (CD14 and IL-8) to predict the age of abrasion and, furthermore, identify the relationshi...

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Bibliographic Details
Published in:Forensic science, medicine, and pathology medicine, and pathology, 2024-03, Vol.20 (1), p.136-148
Main Authors: Pan, Arpan Kumar, Chaudhari, Vinod Ashok, Das, Siddhartha, Gochhait, Debasis, Sontakke, Yogesh Ashok, Harichandrakumar, K. T.
Format: Article
Language:English
Subjects:
Criminology and Criminal Justice
Forensic Medicine
Medicine
Medicine & Public Health
Original Article
Pathology
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Summary:Wound age estimation is a crucial medicolegal task for forensic pathologists. The main objective of the current study was to evaluate the ability of the histopathological profile and immunohistochemical markers (CD14 and IL-8) to predict the age of abrasion and, furthermore, identify the relationship between the histopathological profile and immunohistochemical markers in abrasion aging. The study involved postmortem cases ( n  = 246) of abrasion injuries in which the injury infliction time was known. The test skin samples were taken from the abrasion site, and an adjacent area of uninjured skin was sampled for control. Hematoxylin and eosin stain was applied to tissue sections for the histopathological analysis. The semi-quantitative evaluation was made for expressing immunohistochemical markers CD14 and IL-8 on the infiltrating inflammatory cells. The study showed that the age of abrasion was significantly higher ( p  
ISSN:1556-2891
1556-2891
DOI:10.1007/s12024-023-00611-8