Repurposing of RAS-Pathway Mediated Drugs for Intestinal Inflammation Related Diseases for Treating SARS-CoV-2 Infection

Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is an emerging zoonotic virus, which causes Coronavirus Disease 2019 (COVID-19). Entry of coronaviruses into the cell depends on binding of the viral spike (S) proteins to cellular receptors Angiotensin-converting enzyme 2 (ACE2). The viru...

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Bibliographic Details
Published in:Current microbiology 2023-06, Vol.80 (6), p.194-194, Article 194
Main Authors: Sinha, Anupriya, Vaggu, Raghavendra Goud, Swain, Ramakrushna, Patnaik, Srinivas
Format: Article
Language:English
Subjects:
ACE2
Angiotensin
Angiotensin II
Angiotensin Receptor Antagonists - therapeutic use
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - metabolism
Angiotensin-converting enzyme inhibitors
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biomedical and Life Sciences
Biotechnology
Coronaviruses
COVID-19
Deregulation
Drug Repositioning
Humans
Infections
Inflammation - drug therapy
Inflammatory diseases
Intestine
Life Sciences
Microbiology
Peptidyl-dipeptidase A
Peptidyl-Dipeptidase A - metabolism
Receptors
Renin
Renin-Angiotensin System - physiology
Respiratory diseases
Review Article
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Signal transduction
Signaling
Viral diseases
Viruses
Zoonoses
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Summary:Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is an emerging zoonotic virus, which causes Coronavirus Disease 2019 (COVID-19). Entry of coronaviruses into the cell depends on binding of the viral spike (S) proteins to cellular receptors Angiotensin-converting enzyme 2 (ACE2). The virus-mediated reduction of ACE2/Ang1-7 causes flooding of inflammatory cytokines. A similar scenario of hyper immunologic reaction has been witnessed in the context of Intestinal Inflammatory Diseases (IIDs) with the deregulation of ACE2. This review summarizes several IIDs that lead to such susceptible conditions. It discusses suitable mechanisms of how ACE2, being a crucial regulator of the Renin-Angiotensin System (RAS) signaling pathway, can affect the physiology of intestine as well as lungs, the primary site of SARS-CoV-2 infection. ACE2, as a SARS-CoV-2 receptor, establishes a critical link between COVID-19 and IIDs. Intercessional studies targeting the RAS signaling pathway in patients may provide a novel strategy for addressing the COVID-19 crisis. Hence, the modulation of these key RAS pathway members can be beneficial in both instances. However, it’s difficult to say how beneficial are the ACE inhibitors (ACEI)/ Angiotensin II type-1 receptor blockers (ARBs) during COVID-19. As a result, much more research is needed to better understand the relationship between the RAS and SARS-CoV-2 infection. Graphical Abstract
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-023-03304-1