Looking Beyond the Glomerulus for Cardiovascular Health

• Published in: The American journal of cardiology 2023-06, Vol.196, p.106-106
• Main Authors: Kanmanthareddy, Arun Reddy, Gill, Gauravpal Singh
• Format: Article
• Language: English
• Subjects: Arteriosclerosis; Atherosclerosis; Biomarkers; Cardiovascular disease; Cardiovascular diseases; Cardiovascular System; Chitinase; Creatinine; Diabetes mellitus; Endocrine system; Epidermal growth factor receptors; Fibrosis; Glomerular filtration rate; Glomerulus; Growth factors; Health risks; Heart; Humans; Kidney diseases; Kidney Glomerulus - blood supply; Kidneys; Magnetic resonance imaging; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Plasma; Proteins; Receptors; Renal function; Risk factors; Structure-function relationships; Tumor necrosis factor; Tumor necrosis factor-TNF; U-Plasminogen activator; Urine; Urokinase
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2023.03.013

While in the pathologic state, the dysfunction of 1 system accentuates the pathological progression of the other system.1 Chronic kidney disease is an established risk factor for cardiovascular disease, with nearly 50% prevalence and 50% mortality among patients with stage 4 and 5 chronic kidney disease.2 Traditional measures of renal dysfunction have been glomerular filtration rate, serum creatinine, and albuminuria.3 These are markers of renal glomerular function, and multiple studies have demonstrated that the deterioration levels of these markers are associated with the progression of cardiovascular disease.4,5 In the study “Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in The Multi-Ethnic Study of Atherosclerosis,” Wettersten et al6 analyzed the association between renal tubular biomarkers and cardiac structure and function from the Multi-ethnic study of Atherosclerosis cohort using cardiac magnetic resonance imaging. A total of 12 biomarkers spanning the spectrum of renal tubular injury, function, repair, defense, inflammation, and fibrosis were evaluated in 393 subjects without known evidence of cardiovascular disease, kidney disease, or diabetes. A positive correlation was noted between LVMR and urine monocyte chemoattractant protein (uMCP-1), plasma tumor necrosis factor receptor-1 (pTNFR-1), plasma tumor necrosis factor receptor-2 (pTNFR-2), plasma soluble urokinase plasminogen activator receptor (psuPAR), plasma chitinase-3-like protein 1 (pYKL-40), pKIM-1, plasma monocyte chemoattractant protein 1 (pMCP-1), and urine albumin to urine creatinine ratio (ACR), whereas a negative correlation was observed between LVMR and glomerular filtration rate (eGFR), urine uromodulin (uUMOD), and urine epidermal growth factor (uEGF).