Absolute quantification of myocardial uptake of 99mTc-DPD in patients with cardiac amyloidosis due to transthyretin deposits (ATTR)

• Published in: Revista Española de medicina nuclear e imagen molecular (English ed.) 2023-09, Vol.42 (5), p.302-309
• Main Authors: Sebastián Palacid, Francisco, Álvarez Mena, Noelia, del Carmen Zambrano Infantino, Rosanna, García Aragón, María, Alonso Rodríguez, Mercedes, Pérez López, Berta, Gamazo Laherrán, Claudia, González Soto, María Jesús, Ruano Pérez, Ricardo
• Format: Article
• Language: English
• Subjects: Amiloidosis; Amyloidosis; Captación; Cuantificación; Key words; Quantification; SPECT/CT99mTc-DPD; SPECT/TC99mTc-DPD; Transthyretin; Transtiretina; Uptake
• ISSN: 2253-8089; 2253-8089
• DOI: 10.1016/j.remnie.2023.04.007

To determine the diagnostic contribution of the absolute quantification of the myocardial deposit of 99mTc-DPD in patients with cardiac amyloidosis due to transthyretin deposits (ATTR). SPECT/CT was performed in 41 patients with positive scintigraphic results for ATTR cardiac amyloidosis. The patients were divided into two groups (Perugini grades 2 and 3) and the SUVmax at the level of the bone and both ventricles and the percentage of dose calculated in these areas were calculated. The Student's t-test was used to compare results and the area under the curve (AUC) was calculated to assess differential efficacy and establish discriminatory cut-off points between both groups of patients. Statistically significant differences were observed in all the study variables, with the exception of bone SUVmax. The differences with the greatest statistical power were observed in the variables SUVmaxRV and the percentage of dose in both ventricles (p