The shape anisotropy of magnetic nanoparticles: an approach to cell-type selective and enhanced internalization

The effects of the shape anisotropy of nanoparticles on cellular uptake is still poorly understood due to challenges in the synthesis of anisotropic magnetic nanoparticles of the same composition. Here, we design and synthesize spherical magnetic nanoparticles and their anisotropic assemblies, namel...

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Bibliographic Details
Published in:Nanoscale 2023-05, Vol.15 (19), p.8611-8618
Main Authors: Potr, Tanja, Kralj, Slavko, Nemec, Sebastjan, Kocbek, Petra, Erdani Kreft, Mateja
Format: Article
Language:English
Subjects:
Accumulation
Anisotropy
Biocompatibility
Inductively coupled plasma
Magnetics
Magnetite Nanoparticles
Nanomaterials
Nanoparticles
Shape effects
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Summary:The effects of the shape anisotropy of nanoparticles on cellular uptake is still poorly understood due to challenges in the synthesis of anisotropic magnetic nanoparticles of the same composition. Here, we design and synthesize spherical magnetic nanoparticles and their anisotropic assemblies, namely magnetic nanochains (length ∼800 nm). Then, nanoparticle shape anisotropy is investigated on urothelial cells in vitro . Although both shapes of nanomaterials reveal biocompatibility, we havefound significant differences in the extent of their intracellular accumulation. Contrary to spherical particles, anisotropic nanochains preferentially accumulate in cancer cells as confirmed by inductively coupled plasma (ICP) analysis, indicating that control of the nanoparticle shape geometry governs cell-type-selective intracellular uptake and accumulation. Spherical nanoparticles and anisotropic magnetic nanochains were synthesized, and the impact of their shape anisotropy on cellular uptake was studied. Our findings reveal significant differences in the extent of their intracellular accumulation.
ISSN:2040-3364
2040-3372
DOI:10.1039/d2nr06965b