The Role of Circular RNAs in Ischemic Stroke

Ischemic stroke (IS), a devastating condition characterized by intracranial artery stenosis and middle cerebral artery occlusion leading to insufficient oxygen supply to the brain, is a major cause of death and physical disability worldwide. Recent research has demonstrated the critical role of circ...

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Bibliographic Details
Published in:Neurochemical research 2023-09, Vol.48 (9), p.2607-2620
Main Authors: Jiang, Weiwei, Long, Xiongquan, Li, Zhicheng, Hu, Mi, Zhang, Yangkai, Lin, Huiling, Tang, Wanying, Ouyang, Yuxin, Jiang, Liping, Chen, Jinzhi, He, Pingping, Ouyang, Xinping
Format: Article
Language:English
Subjects:
Alzheimer's disease
Apoptosis
Autophagy
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biosynthesis
Brain research
Cell Biology
Cerebral blood flow
Circular RNA
Hospitals
Inflammation
Ischemia
Neurochemistry
Neurology
Neurosciences
Occlusion
Physiology
Plastic foam
Review
RNA polymerase
Stenosis
Stroke
Synaptic plasticity
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Summary:Ischemic stroke (IS), a devastating condition characterized by intracranial artery stenosis and middle cerebral artery occlusion leading to insufficient oxygen supply to the brain, is a major cause of death and physical disability worldwide. Recent research has demonstrated the critical role of circular RNAs (circRNAs), a class of covalently enclosed noncoding RNAs that are widespread in eukaryotic cells, in regulating various physiological and pathophysiological cellular processes, including cell apoptosis, autophagy, synaptic plasticity, and neuroinflammation. In the past few years, circRNAs have attracted extensive attention in the field of IS research. This review summarizes the current understanding of the mechanisms underlying the involvement of circRNAs in IS development. A better understanding of circRNA-mediated pathogenic mechanisms in IS may pave the way for translating circRNA research into clinical practice, ultimately improving the clinical outcomes of IS patients.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-023-03935-7