Preliminary study of the interactive effects of coronary heart disease and lacunar infarction on renal function in patients with type 2 diabetes mellitus by gender

• Published in: Journal of diabetes and its complications 2023-06, Vol.37 (6), p.108477-108477, Article 108477
• Main Authors: Li, Hongdian, Li, Mingxuan, Dong, Shaoning, Dong, Ao, Wang, Jing, Zhu, Yuanyuan, Deng, Yuanyuan, Chen, Shu, Zhang, Mianzhi
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Aged; Body mass index; Cardiovascular disease; Chinese medicine; Cholesterol; Cholesterol, LDL; Chronic illnesses; Chronic kidney disease; Collaboration; Coronary Disease - complications; Coronary Disease - epidemiology; Coronary heart disease; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Epidemiology; Female; Glucose; Hospitals; Humans; Hypertension; Interactive effect; Kidney - physiology; Kidney diseases; Lacunar infarction; Magnetic resonance imaging; Male; Middle Aged; Questionnaires; Risk Factors; Smoking; Stroke, Lacunar - complications; Type 2 diabetes mellitus
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2023.108477

Coronary heart disease (CHD) and lacunar infarction (LI) are the most common cardio- cerebrovascular complications of type 2 diabetes mellitus (T2DM) and a recognized risk factor for renal injury. Although a unidirectional association of CHD or LI with T2DM or the kidney has been demonstrated, however, it remains unknown whether there is an interactive effect of the coexistence of CHD and LI on renal function in T2DM patients. The aim of our study was to investigate the interaction between CHD and LI on renal function in gender-specific patients with T2DM and the association between cardio-cerebrovascular disease-related conventional serum markers and the estimated glomerular filtration rate (eGFR). We conducted a cross-sectional study in Beijing and Tianjin from April 2019 to August 2021. Participants with T2DM aged ≥18 years were asked to complete a one-to-one questionnaire and physical examination. In this study, 389 eligible patients with T2DM were included, with a mean age of 63.04 ± 9.41 years, of whom 200 (51.41 %) were male. The proportions of patients with CHD, LI, and both CHD and LI were 28.53 %, 24.42 %, and 11.05 %, respectively. Compared to T2DM patients without either CHD or LI, those with both CHD and LI were found to have a significantly greater risk of reduced eGFR (OR: 12.82, 95 % CI 5.06–32.52, P