The prognostic significance of non-lymphoid immune cells of the tumor microenvironment, including neutrophils, eosinophils, and mast cells in breast carcinomas

The prognostic importance of lymphoid cells in the tumor microenvironment and their effect on treatment response have been demonstrated in many cancer types. However, there are limited studies on non-lymphoid immune cells. Conflicting results have been obtained regarding the effects of these cells o...

Full description

Saved in:
Bibliographic Details
Published in:Annals of diagnostic pathology 2023-08, Vol.65, p.152151-152151, Article 152151
Main Authors: Okcu, Oğuzhan, Öztürk, Çiğdem, Şen, Bayram, Ayazoğlu, Muhammet Safa, Güvendi, Gülname Fındık, Öztürk, Seda Duman, Aşkan, Gökçe, Bedir, Recep
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Breast Neoplasms - metabolism
Eosinophil
Eosinophils - pathology
Female
Humans
Invasive breast carcinoma
Ki-67 Antigen - metabolism
Lymphocytes - pathology
Mast cell
Mast Cells - pathology
Neutrophil
Neutrophils - pathology
Prognosis
Receptor, ErbB-2 - metabolism
Receptors, Progesterone - metabolism
Tumor Microenvironment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The prognostic importance of lymphoid cells in the tumor microenvironment and their effect on treatment response have been demonstrated in many cancer types. However, there are limited studies on non-lymphoid immune cells. Conflicting results have been obtained regarding the effects of these cells on prognosis. A total of 331 patients who underwent surgery for breast cancer were included. Patients that received neoadjuvant chemotherapy and those with distant metastasis were excluded. CD 15 immunohistochemistry was performed to detect tumor-infiltrating neutrophils (TINs) and eosinophils (TIEs), while Toluidine Blue histochemistry was performed to detect tumor-infiltrating mast cells (TIMs). High TINs were statistically associated with low ER expression (p 
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2023.152151