Pancoronary plaque characteristics and clinical outcomes in acute coronary syndrome patients with cancer history

• Published in: Atherosclerosis 2023-08, Vol.378, p.117118-117118, Article 117118
• Main Authors: Wang, Chao, Tian, Xueqin, Feng, Xue, Demuyakor, Abigail, Hu, Sining, Wang, Yini, Li, Lulu, Cui, Lina, Dong, Fuhong, Dai, Jiannan, Lei, Fangmeng, Xu, Yishuo, Du, Zhuo, Shi, Manru, Liu, Jiayin, Xing, Lei, E, Mingyan
• Format: Article
• Language: English
• Subjects: Acute coronary syndrome; Cancer history; Optical coherence tomography; Outcomes; Plaque characteristics
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2023.03.023

The prevalence of acute coronary syndrome (ACS) patients with cancer history is increasing and it is associated with higher mortality. However, there is limited evidence on the characteristics of coronary plaque in ACS patients with cancer history. This study explored the pancoronary plaque characteristics in ACS patients with cancer history by optical coherence tomography (OCT). A total of 306 ACS patients treated by 3-vessel OCT at the time of percutaneous coronary intervention (PCI) were included, retrospectively. Patients were divided into two groups according to the presence or absence of cancer history: one group with cancer history (n = 98) and a matched group without cancer history (n = 208). A total of 314 culprit lesions and 514 nonculprit lesions were identified by OCT in this study. In culprit lesions, ACS patients with cancer history had higher incidence of thin cap fibroatheroma (TCFA) (p = 0.016), cholesterol crystals (p = 0.028), calcification (p = 0.001) and thrombus (p = 0.001), and had thinner fibrous cap thickness (FCT) (p = 0.011), greater maximum lipid arc (p = 0.042) and lipid index (p