Infectious agents and pathogenesis of Behçet's disease: An extensive review

Behçet's disease (BD) is a multisystemic chronic vasculitis. Sustained and enhanced immune responses were reportedly associated with active BD. Although genetic polymorphisms increase development risk, genetic factors alone cannot account for BD development, suggesting the involvement of exogen...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2023-06, Vol.251, p.109631-109631, Article 109631
Main Authors: Cheng, Linlin, Zhan, Haoting, Liu, Yongmei, Chen, Hua, Zhang, Fengchun, Zheng, Wenjie, Li, Yongzhe
Format: Article
Language:English
Subjects:
Bacteria
Behcet Syndrome
Behçet's disease
Etiology
Fungus
Humans
Infection
Risk Factors
Vasculitis - complications
Virus
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Summary:Behçet's disease (BD) is a multisystemic chronic vasculitis. Sustained and enhanced immune responses were reportedly associated with active BD. Although genetic polymorphisms increase development risk, genetic factors alone cannot account for BD development, suggesting the involvement of exogenous factors. Also, how various infectious agents promote BD in high-risk populations is not fully understood. In this review, we summarized the current findings on the associations of infectious agents with BD pathogenesis. The review also highlights the potential microbial risk factors and their pathogenic role in BD progression. Interactions between genetic and infectious risk factors was also discussed. Furthermore, evidence implied that after the eradication of infectious agents, BD symptoms and recurrence decreased, thus highlighting that combined use of antibiotics may be an effective therapy for BD. Finally, we summarized the main limitation of the current related studies, providing valuable insights and a basis for future studies on BD pathogenic factors.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2023.109631