Association between high-density lipoprotein cholesterol to apolipoprotein A ratio and diabetic retinopathy: A cross-sectional study

Our study is aimed to investigate the relationship between high-density lipoprotein cholesterol to apolipoprotein A ratio (HDL-C/ApoA) and diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). We retrospect the consecutive medical files of 1058 subjects with T2DM and recorded t...

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Published in:Journal of diabetes and its complications 2023-06, Vol.37 (6), p.108471-108471, Article 108471
Main Authors: Zhang, Cong, Lin, Wenjian, Xu, Qian, Li, Hongxue, Xu, Chengye, Ma, Xuefei, Hao, Ming, Kuang, Hongyu
Format: Article
Language:English
Subjects:
Apolipoprotein A-I
Apolipoproteins
Apolipoproteins A
Autoimmune diseases
Blood transfusions
Cardiovascular disease
Cholesterol
Cholesterol, HDL
Coronary vessels
Cross-Sectional Studies
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetic retinopathy
Diabetic Retinopathy - complications
Diabetic Retinopathy - epidemiology
Glucose
HDL-C/ApoA
Hematology
High density lipoprotein
Hospitals
Humans
Insulin
Laboratories
Lipids
Lipoproteins
Medical personnel
Medical research
Normal distribution
Patients
Peptides
Regression analysis
Stroke
Type 2 diabetes mellitus
Uric acid
Variables
Vein & artery diseases
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Summary:Our study is aimed to investigate the relationship between high-density lipoprotein cholesterol to apolipoprotein A ratio (HDL-C/ApoA) and diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). We retrospect the consecutive medical files of 1058 subjects with T2DM and recorded their clinical information and laboratory findings. Subjects with T2DM were divided into DR group (n = 522) and non-DR group (n = 536). We compared the lipids values of the two groups. Meanwhile we also observed the prevalence of DR at different HDL-C/ApoA levels. Binary logistic regression was used to correct confounding factors. Smooth curve fitting model and subgroup analysis were used to determine the correlation, non-linear relationship and threshold effect between HDL/ApoA and DR. HDL-C/ApoA value of DR group was significantly higher than non-DR group (0.88 ± 0.17 vs 0.84 ± 0.13, P 0.759, HDL/ApoA was significantly positively associated with DR (HR = 26.508, 95 % CI 7.623–92.174; P 
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2023.108471