Hyperoxia-induced lung injury in acute respiratory distress syndrome: what is its relative impact?

Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached r...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2023-07, Vol.325 (1), p.L9-L16
Main Authors: Lilien, Thijs A, van Meenen, David M P, Schultz, Marcus J, Bos, Lieuwe D J, Bem, Reinout A
Format: Article
Language:English
Subjects:
Clinical trials
Humans
Hyperoxia
Hyperoxia - complications
Lung Injury
Lungs
Oxygen
Oxygenation
Respiration, Artificial - adverse effects
Respiratory distress syndrome
Respiratory Distress Syndrome - etiology
Toxicity
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Summary:Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached regarding the clinical impact of hyperoxia and hyperoxemia. In this perspective article, we explore the experimental and clinical evidence on hyperoxia-induced lung injury (HILI) and assess its relative impact in current critical care practice, specifically in patients who require oxygen therapy due to acute respiratory distress syndrome (ARDS). Here, we suggest that in current clinical practice in the setting of ARDS HILI may actually be of less importance than other ventilator-related factors.
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.00443.2022