Denosumab for osteoporosis in patients with primary hyperparathyroidism and mild-to-moderate renal insufficiency

Purpose We aimed to assess the efficacy and safety of denosumab in postmenopausal women with primary hyperparathyroidism (PHPT)-related osteoporosis and chronic kidney disease (CKD). Methods Women over 50 years of age with PHPT or postmenopausal osteoporosis (PMO) were retrospectively recruited into...

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Bibliographic Details
Published in:Endocrine 2023-08, Vol.81 (2), p.368-378
Main Authors: Gronskaya, Sofia, Belaya, Zhanna, Rozhinskaya, Liudmila, Mamedova, Elizaveta, Vorontsova, Maria, Solodovnikov, Alexander, Golounina, Olga, Melnichenko, Galina
Format: Article
Language:English
Subjects:
Aged
Bone Density
Bone Density Conservation Agents - adverse effects
Bone mineral density
Calcium
Calcium (blood)
Denosumab - therapeutic use
Diabetes
Endocrinology
Female
Femur
Glomerular filtration rate
Humanities and Social Sciences
Humans
Hyperparathyroidism
Hyperparathyroidism, Primary - complications
Hyperparathyroidism, Primary - drug therapy
Internal Medicine
Kidney diseases
Longitudinal Studies
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Original Article
Osteoporosis
Osteoporosis - chemically induced
Osteoporosis - etiology
Osteoporosis, Postmenopausal - drug therapy
Post-menopause
Radius
Renal insufficiency
Renal Insufficiency - chemically induced
Renal Insufficiency - complications
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - drug therapy
Retrospective Studies
Science
Citations: Items that this one cites
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Summary:Purpose We aimed to assess the efficacy and safety of denosumab in postmenopausal women with primary hyperparathyroidism (PHPT)-related osteoporosis and chronic kidney disease (CKD). Methods Women over 50 years of age with PHPT or postmenopausal osteoporosis (PMO) were retrospectively recruited into this longitudinal study. These PHPT and PMO groups were further categorized into subgroups based on the presence of CKD (Glomerular filtration rate (GFR) 
ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-023-03381-z