NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy

An NQO1-responsive precursor, named R848-QPA , has been developed to evoke an anti-tumor immune response. R848-QPA can induce innate immune activation when activated by overexpressed NQO1 in the tumor microenvironment while showing lower activity in NQO1-deprived environments. This strategy provides...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-05, Vol.59 (42), p.6343-6346
Main Authors: Li, Guo, Xu, Yongxiao, Kong, Xiaojie, Gu, Liuwei, Qin, Yuling, Wu, Li
Format: Article
Language:English
Subjects:
Humans
Immune system
NAD
NAD(P)H Dehydrogenase (Quinone)
Neoplasms - drug therapy
Prodrugs - pharmacology
Proteins
Quinones
Quinones - pharmacology
Toll-Like Receptor 7
Tumor Microenvironment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c337t-92f5380594535ea386af15bdd2b4b670cae8b62a026370e6d55f404bac256e053
cites cdi_FETCH-LOGICAL-c337t-92f5380594535ea386af15bdd2b4b670cae8b62a026370e6d55f404bac256e053
container_end_page 6346
container_issue 42
container_start_page 6343
container_title Chemical communications (Cambridge, England)
container_volume 59
creator Li, Guo
Xu, Yongxiao
Kong, Xiaojie
Gu, Liuwei
Qin, Yuling
Wu, Li
description An NQO1-responsive precursor, named R848-QPA , has been developed to evoke an anti-tumor immune response. R848-QPA can induce innate immune activation when activated by overexpressed NQO1 in the tumor microenvironment while showing lower activity in NQO1-deprived environments. This strategy provides a new method for the development of tumor-microenvironment-responsive prodrugs for antitumor immunotherapy. An NQO1-responsive agonist has been developed to evoke an anti-tumor immune response, providing a new concept for tumor-microenvironment-responsive prodrug design to achieve precise immunotherapy.
doi_str_mv 10.1039/d3cc00663h
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2809005762</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2817581037</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-92f5380594535ea386af15bdd2b4b670cae8b62a026370e6d55f404bac256e053</originalsourceid><addsrcrecordid>eNpd0U1L5TAUBuAgil_jxr0ScKNCNWmapHUnV2euIM4sFNyVNDnVaNv0JqnovzfOdRQmmwTOw0s4L0K7lJxQwqpTw7QmRAj2uII2KRNFxovyfvXjzatMsoJvoK0Qnkg6lJfraINJynJBik3kbs4vDv8czc_wYrKDGwC7V2ucBzPpqAJgipWO9kVF1XSAo-u6rLPPgD1oGKPzWJ6WWD24wYaIDQT7MIDBbRqMidiUYPt-Glx8BK_Gtx9orVVdgJ3Pexvd_by8nc2z69-_rmbn15lmTMasylvOSsKrgjMOipVCtZQ3xuRN0QhJtIKyEbkiuWCSgDCctwUpGqVzLoBwto0Ol7mjd4sJQqx7GzR0nRrATaHOS1IRwqXIEz34jz65yQ_pd0lRycu0ZJnU8VJp70Lw0Najt73ybzUl9UcN9QWbzf7WME94_zNyanowX_Tf3hPYWwIf9Nf0u0f2DhHLi0Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2817581037</pqid></control><display><type>article</type><title>NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy</title><source>Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)</source><creator>Li, Guo ; Xu, Yongxiao ; Kong, Xiaojie ; Gu, Liuwei ; Qin, Yuling ; Wu, Li</creator><creatorcontrib>Li, Guo ; Xu, Yongxiao ; Kong, Xiaojie ; Gu, Liuwei ; Qin, Yuling ; Wu, Li</creatorcontrib><description>An NQO1-responsive precursor, named R848-QPA , has been developed to evoke an anti-tumor immune response. R848-QPA can induce innate immune activation when activated by overexpressed NQO1 in the tumor microenvironment while showing lower activity in NQO1-deprived environments. This strategy provides a new method for the development of tumor-microenvironment-responsive prodrugs for antitumor immunotherapy. An NQO1-responsive agonist has been developed to evoke an anti-tumor immune response, providing a new concept for tumor-microenvironment-responsive prodrug design to achieve precise immunotherapy.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d3cc00663h</identifier><identifier>PMID: 37132604</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Humans ; Immune system ; NAD ; NAD(P)H Dehydrogenase (Quinone) ; Neoplasms - drug therapy ; Prodrugs - pharmacology ; Proteins ; Quinones ; Quinones - pharmacology ; Toll-Like Receptor 7 ; Tumor Microenvironment</subject><ispartof>Chemical communications (Cambridge, England), 2023-05, Vol.59 (42), p.6343-6346</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-92f5380594535ea386af15bdd2b4b670cae8b62a026370e6d55f404bac256e053</citedby><cites>FETCH-LOGICAL-c337t-92f5380594535ea386af15bdd2b4b670cae8b62a026370e6d55f404bac256e053</cites><orcidid>0000-0002-4118-7970 ; 0000-0003-2819-8592</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37132604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Guo</creatorcontrib><creatorcontrib>Xu, Yongxiao</creatorcontrib><creatorcontrib>Kong, Xiaojie</creatorcontrib><creatorcontrib>Gu, Liuwei</creatorcontrib><creatorcontrib>Qin, Yuling</creatorcontrib><creatorcontrib>Wu, Li</creatorcontrib><title>NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>An NQO1-responsive precursor, named R848-QPA , has been developed to evoke an anti-tumor immune response. R848-QPA can induce innate immune activation when activated by overexpressed NQO1 in the tumor microenvironment while showing lower activity in NQO1-deprived environments. This strategy provides a new method for the development of tumor-microenvironment-responsive prodrugs for antitumor immunotherapy. An NQO1-responsive agonist has been developed to evoke an anti-tumor immune response, providing a new concept for tumor-microenvironment-responsive prodrug design to achieve precise immunotherapy.</description><subject>Humans</subject><subject>Immune system</subject><subject>NAD</subject><subject>NAD(P)H Dehydrogenase (Quinone)</subject><subject>Neoplasms - drug therapy</subject><subject>Prodrugs - pharmacology</subject><subject>Proteins</subject><subject>Quinones</subject><subject>Quinones - pharmacology</subject><subject>Toll-Like Receptor 7</subject><subject>Tumor Microenvironment</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0U1L5TAUBuAgil_jxr0ScKNCNWmapHUnV2euIM4sFNyVNDnVaNv0JqnovzfOdRQmmwTOw0s4L0K7lJxQwqpTw7QmRAj2uII2KRNFxovyfvXjzatMsoJvoK0Qnkg6lJfraINJynJBik3kbs4vDv8czc_wYrKDGwC7V2ucBzPpqAJgipWO9kVF1XSAo-u6rLPPgD1oGKPzWJ6WWD24wYaIDQT7MIDBbRqMidiUYPt-Glx8BK_Gtx9orVVdgJ3Pexvd_by8nc2z69-_rmbn15lmTMasylvOSsKrgjMOipVCtZQ3xuRN0QhJtIKyEbkiuWCSgDCctwUpGqVzLoBwto0Ol7mjd4sJQqx7GzR0nRrATaHOS1IRwqXIEz34jz65yQ_pd0lRycu0ZJnU8VJp70Lw0Najt73ybzUl9UcN9QWbzf7WME94_zNyanowX_Tf3hPYWwIf9Nf0u0f2DhHLi0Y</recordid><startdate>20230523</startdate><enddate>20230523</enddate><creator>Li, Guo</creator><creator>Xu, Yongxiao</creator><creator>Kong, Xiaojie</creator><creator>Gu, Liuwei</creator><creator>Qin, Yuling</creator><creator>Wu, Li</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4118-7970</orcidid><orcidid>https://orcid.org/0000-0003-2819-8592</orcidid></search><sort><creationdate>20230523</creationdate><title>NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy</title><author>Li, Guo ; Xu, Yongxiao ; Kong, Xiaojie ; Gu, Liuwei ; Qin, Yuling ; Wu, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-92f5380594535ea386af15bdd2b4b670cae8b62a026370e6d55f404bac256e053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Humans</topic><topic>Immune system</topic><topic>NAD</topic><topic>NAD(P)H Dehydrogenase (Quinone)</topic><topic>Neoplasms - drug therapy</topic><topic>Prodrugs - pharmacology</topic><topic>Proteins</topic><topic>Quinones</topic><topic>Quinones - pharmacology</topic><topic>Toll-Like Receptor 7</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Guo</creatorcontrib><creatorcontrib>Xu, Yongxiao</creatorcontrib><creatorcontrib>Kong, Xiaojie</creatorcontrib><creatorcontrib>Gu, Liuwei</creatorcontrib><creatorcontrib>Qin, Yuling</creatorcontrib><creatorcontrib>Wu, Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Guo</au><au>Xu, Yongxiao</au><au>Kong, Xiaojie</au><au>Gu, Liuwei</au><au>Qin, Yuling</au><au>Wu, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2023-05-23</date><risdate>2023</risdate><volume>59</volume><issue>42</issue><spage>6343</spage><epage>6346</epage><pages>6343-6346</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>An NQO1-responsive precursor, named R848-QPA , has been developed to evoke an anti-tumor immune response. R848-QPA can induce innate immune activation when activated by overexpressed NQO1 in the tumor microenvironment while showing lower activity in NQO1-deprived environments. This strategy provides a new method for the development of tumor-microenvironment-responsive prodrugs for antitumor immunotherapy. An NQO1-responsive agonist has been developed to evoke an anti-tumor immune response, providing a new concept for tumor-microenvironment-responsive prodrug design to achieve precise immunotherapy.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37132604</pmid><doi>10.1039/d3cc00663h</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-4118-7970</orcidid><orcidid>https://orcid.org/0000-0003-2819-8592</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1359-7345
ispartof Chemical communications (Cambridge, England), 2023-05, Vol.59 (42), p.6343-6346
issn 1359-7345
1364-548X
language eng
recordid cdi_proquest_miscellaneous_2809005762
source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Humans
Immune system
NAD
NAD(P)H Dehydrogenase (Quinone)
Neoplasms - drug therapy
Prodrugs - pharmacology
Proteins
Quinones
Quinones - pharmacology
Toll-Like Receptor 7
Tumor Microenvironment
title NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T17%3A16%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=NAD(P)H:%20quinone%20oxidoreductase%201%20activatable%20toll-like%20receptor%207/8%20agonist%20designed%20for%20precise%20immunotherapy&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Li,%20Guo&rft.date=2023-05-23&rft.volume=59&rft.issue=42&rft.spage=6343&rft.epage=6346&rft.pages=6343-6346&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/d3cc00663h&rft_dat=%3Cproquest_cross%3E2817581037%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c337t-92f5380594535ea386af15bdd2b4b670cae8b62a026370e6d55f404bac256e053%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2817581037&rft_id=info:pmid/37132604&rfr_iscdi=true