An assessment of the downstream implications of blood culture collection and transit

   The implications of the variables within the pre-analytical phase of blood culture processing are poorly understood. This study aims to explore the effect of transit times (TT) and culture volume, on time to microbiological diagnosis and patient outcomes. Blood cultures received between 1st March...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2023-07, Vol.42 (7), p.835-842
Main Authors: Davies, Peter J. B., Jones, Timothy P. W., Macleod, Mairi
Format: Article
Language:English
Subjects:
Antibiotics
Bacteremia
Biomedical and Life Sciences
Biomedicine
Blood
Blood culture
Clinical outcomes
Culture
Infectious diseases
Internal Medicine
Ions
Laboratories
Length of stay
Mass spectrometry
Medical Microbiology
Microbiology
Mortality
Organisms
Original Article
Patients
Scientific imaging
Statistical analysis
Streptococcus infections
Transit time
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Summary:   The implications of the variables within the pre-analytical phase of blood culture processing are poorly understood. This study aims to explore the effect of transit times (TT) and culture volume, on time to microbiological diagnosis and patient outcomes. Blood cultures received between 1st March and 31st July 2020/21 were identified. TT, time in incubator (TII), and for positive samples, request to positivity times (RPT) were calculated. Demographic details were recorded for all samples, and culture volume, length of stay (LoS), and 30-day mortality for patients with positive samples. Statistical analysis examined how culture volume and TT effected culture positivity and outcome; in the context of the 4-h national TT target. Totally, 14,375 blood culture bottles were received from 7367 patients; 988 (13.4%) were positive for organisms. There was no significant difference between TT of negative and positive samples. The RPT was significantly lower for samples with TT 
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-023-04610-z