Self-Rupturing Microcapsules

Self‐rupturing microcapsules are prepared by layer‐by‐layer coating of degradable dextran‐hydroxyethyl methacrylate microgels with the polyelectrolytes poly(allylamine hydrochloride) and sodium poly(styrene sulfonate). When the microgel core degrades, the swelling pressure increases and, at a critic...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2005-10, Vol.17 (19), p.2357-2361
Main Authors: De Geest, B. G., Déjugnat, C., Sukhorukov, G. B., Braeckmans, K., De Smedt, S. C., Demeester, J.
Format: Article
Language:English
Subjects:
Biomedical applications
Drug delivery
Layer-by-layer assembly
Microcapsules
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Summary:Self‐rupturing microcapsules are prepared by layer‐by‐layer coating of degradable dextran‐hydroxyethyl methacrylate microgels with the polyelectrolytes poly(allylamine hydrochloride) and sodium poly(styrene sulfonate). When the microgel core degrades, the swelling pressure increases and, at a critical value of the swelling pressure, the surrounding membrane suddenly ruptures (see Figure). This type of microcapsule could be very promising for pulsed drug delivery.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200401951