Catalytic C-H alkynylation of benzylamines and aldehydes with aldimine-directing groups generated in situ

Iridium-catalysed regioselective C-H alkynylation of unprotected primary benzylamines and aliphatic aldehydes has been achieved using in situ-installed aldimine directing groups. This protocol provides a straightforward route for the synthesis of the alkynylated primary benzylamine and aliphatic ald...

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Published in:Chemical communications (Cambridge, England) England), 2023-05, Vol.59 (42), p.6355-6358
Main Authors: Zhou, Jiao, Jiao, Tenggang, Fu, Qiang, Wang, Jun, Lu, Ji, Yang, Lin, Wei, Jun, Wei, Siping, Cong, Xuefeng, Hao, Na
Format: Article
Language:English
Subjects:
Aldehydes
Aliphatic compounds
Iridium
Regioselectivity
Substrates
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container_title Chemical communications (Cambridge, England)
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creator Zhou, Jiao
Jiao, Tenggang
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description Iridium-catalysed regioselective C-H alkynylation of unprotected primary benzylamines and aliphatic aldehydes has been achieved using in situ-installed aldimine directing groups. This protocol provides a straightforward route for the synthesis of the alkynylated primary benzylamine and aliphatic aldehyde derivatives, featuring good substrate compatibility and high regioselectivity.
doi_str_mv 10.1039/d3cc01414b
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subjects Aldehydes
Aliphatic compounds
Iridium
Regioselectivity
Substrates
title Catalytic C-H alkynylation of benzylamines and aldehydes with aldimine-directing groups generated in situ
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