Boosting ultralong chemiluminescence for the self-powered time-resolved immunosensor

The construction of an immunosensor based on ultralong chemiluminescence is challenged due to the shortage of highly efficient initiator for long and stable catalysis. Herein, the heterogeneous Au/Pt@CuO/Cu2O catalyst was used to investigate the structure-activity relationship, while Au/Pt significa...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2023-08, Vol.234, p.115338-115338, Article 115338
Main Authors: Qileng, Aori, Chen, Shizhang, Liang, Hongzhi, Chen, Mengting, Lei, Hongtao, Liu, Weipeng, Liu, Yingju
Format: Article
Language:English
Subjects:
Biosensing Techniques - methods
Chemluminescence
Electrochemical Techniques - methods
Heterogeneous fenton catalyst
Hydrogen Peroxide
Immunoassay - methods
Limit of Detection
Luminescence
Photoelectrochemical
Pt–O–Cu
Self-powered immunosensor
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Summary:The construction of an immunosensor based on ultralong chemiluminescence is challenged due to the shortage of highly efficient initiator for long and stable catalysis. Herein, the heterogeneous Au/Pt@CuO/Cu2O catalyst was used to investigate the structure-activity relationship, while Au/Pt significantly promotes the activity of CuO/Cu2O to catalyze H2O2 and thus produces ·OH and O2•- radicals in highly alkaline solutions, resulting in the strong and long chemiluminescence in the reaction with luminol (10 mL, more than 4 min with 1 μg catalyst). By using the Au/Pt@CuO/Cu2O as the label in the immunoassay, the strong and long chemiluminescence could initiate the photocurrent of the photoelectrochemical (PEC) substrate, and the luminescence time could influence the photocurrent extinction time, thus a self-powered time-resolved PEC immunosensor was developed to detect furosemide, showing a linear relationship between the extinction time and the logarithm of concentrations from 10−3 to 1 μg/L. This work not only experimentally verifies that the Pt–O–Cu bond in heterogeneous catalysts breaks the pH limitation of the Fenton reaction, but also realizes the chemiluminescence for self-powered time-resolved immunosensor, thereby expanding the portable applicability of chemiluminescence in food safety inspection, health monitoring, and biomedical detection without external light source. [Display omitted]
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2023.115338