Pre-operative Cinacalcet Administration Reduces Immediate Post-operative Hypocalcemia Following Total Parathyroidectomy in Severe Renal Hyperparathyroidism

Background In severe renal hyperparathyroidism (RHPT), whether administrating Cinacalcet before total parathyroidectomy can reduce post-operative hypocalcemia remains unclear. We compared post-operative calcium kinetics between those who took Cinacalcet before surgery (Group I) and those who did not...

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Bibliographic Details
Published in:World journal of surgery 2023-08, Vol.47 (8), p.1986-1994
Main Authors: Fung, Matrix Man-Him, Tam, Dick-Sang, Lui, David Tak-Wai, Lang, Brian Hung-Hin
Format: Article
Language:English
Subjects:
Abdominal Surgery
Calcium
Cardiac Surgery
Cinacalcet - therapeutic use
Correlation
Dietary supplements
General Surgery
Humans
Hypercalcemia
Hyperparathyroidism
Hyperparathyroidism - surgery
Hyperparathyroidism, Secondary - drug therapy
Hyperparathyroidism, Secondary - surgery
Hypocalcemia
Hypocalcemia - etiology
Hypocalcemia - prevention & control
Medicine
Medicine & Public Health
Original Scientific Report
Parathyroid Hormone
Parathyroidectomy
Retrospective Studies
Serum albumin
Surgery
Thoracic Surgery
Treatment Outcome
Vascular Surgery
Vitamin D
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Summary:Background In severe renal hyperparathyroidism (RHPT), whether administrating Cinacalcet before total parathyroidectomy can reduce post-operative hypocalcemia remains unclear. We compared post-operative calcium kinetics between those who took Cinacalcet before surgery (Group I) and those who did not (Group II). Methods Patients with severe RHPT (defined by PTH ≥ 100 pmol/L) who underwent total parathyroidectomy between 2012 and 2022 were analyzed. Standardized peri-operative protocol of calcium and vitamin D supplementation was followed. Blood tests were performed twice daily in the immediate post-operative period. Severe hypocalcemia was defined as serum albumin-adjusted calcium 
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-023-07030-4