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Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives
Two novel bis-tridentate imidazole derivatives were conveniently synthesized using a ‘one-pot’ method. Their dinuclear (Cu 2 L 1 Cl 4 , Cu 2 L 2 Cl 4 ) and mononuclear (CuL 1 Cl 2 , CuL 2 Cl 2 ∙H 2 O) copper (II) complexes were synthesized to comparably evaluate their reactivities in the hydrolytic...
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| Published in: | Journal of biological inorganic chemistry 2023-08, Vol.28 (5), p.473-483 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c375t-a5ab581434dff55ede64443d4eb1f3aad4b3d233b0a04d9f9ab92c10cde9edfc3 |
| container_end_page | 483 |
| container_issue | 5 |
| container_start_page | 473 |
| container_title | Journal of biological inorganic chemistry |
| container_volume | 28 |
| creator | Wang, Xiuyang Shu, Jun Ni, Tong Xu, Chengxu Xu, Bin Liu, Xiaoqiang Zhang, Kaiming Jiang, Weidong |
| description | Two novel bis-tridentate imidazole derivatives were conveniently synthesized using a ‘one-pot’ method. Their dinuclear (Cu
2
L
1
Cl
4
, Cu
2
L
2
Cl
4
) and mononuclear (CuL
1
Cl
2
, CuL
2
Cl
2
∙H
2
O) copper (II) complexes were synthesized to comparably evaluate their reactivities in the hydrolytic cleavage of 2-hydroxypropyl p-nitrophenyl phosphate (HPNP) as a classic RNA model. Single crystals of Cu
2
L
1
Cl
4
and Cu
2
L
2
Cl
4
indicate that both of them are centrosymmetric, and each central copper ion is penta-coordinated. Regarding the transesterification of HPNP, both of dinuclear ones exhibited excess one order of magnitude rate enhancement in contrast with auto-hydrolysis reaction. Under comparable conditions, dinuclear complexes displayed no more than twofold increase in activity over their mononuclear analogues, which verifies the lack of binuclear cooperation effect due to long Cu-to-Cu space.
Graphical Abstract |
| doi_str_mv | 10.1007/s00775-023-02000-6 |
| format | article |
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2
L
1
Cl
4
, Cu
2
L
2
Cl
4
) and mononuclear (CuL
1
Cl
2
, CuL
2
Cl
2
∙H
2
O) copper (II) complexes were synthesized to comparably evaluate their reactivities in the hydrolytic cleavage of 2-hydroxypropyl p-nitrophenyl phosphate (HPNP) as a classic RNA model. Single crystals of Cu
2
L
1
Cl
4
and Cu
2
L
2
Cl
4
indicate that both of them are centrosymmetric, and each central copper ion is penta-coordinated. Regarding the transesterification of HPNP, both of dinuclear ones exhibited excess one order of magnitude rate enhancement in contrast with auto-hydrolysis reaction. Under comparable conditions, dinuclear complexes displayed no more than twofold increase in activity over their mononuclear analogues, which verifies the lack of binuclear cooperation effect due to long Cu-to-Cu space.
Graphical Abstract</description><identifier>ISSN: 1432-1327</identifier><identifier>ISSN: 0949-8257</identifier><identifier>EISSN: 1432-1327</identifier><identifier>DOI: 10.1007/s00775-023-02000-6</identifier><identifier>PMID: 37140680</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Copper ; Crystals ; Imidazole ; Inorganic chemistry ; Life Sciences ; Microbiology ; Original Paper ; p-Nitrophenylphosphate</subject><ispartof>Journal of biological inorganic chemistry, 2023-08, Vol.28 (5), p.473-483</ispartof><rights>The Author(s), under exclusive licence to Society for Biological Inorganic Chemistry (SBIC) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Society for Biological Inorganic Chemistry (SBIC).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a5ab581434dff55ede64443d4eb1f3aad4b3d233b0a04d9f9ab92c10cde9edfc3</citedby><cites>FETCH-LOGICAL-c375t-a5ab581434dff55ede64443d4eb1f3aad4b3d233b0a04d9f9ab92c10cde9edfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37140680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiuyang</creatorcontrib><creatorcontrib>Shu, Jun</creatorcontrib><creatorcontrib>Ni, Tong</creatorcontrib><creatorcontrib>Xu, Chengxu</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><creatorcontrib>Liu, Xiaoqiang</creatorcontrib><creatorcontrib>Zhang, Kaiming</creatorcontrib><creatorcontrib>Jiang, Weidong</creatorcontrib><title>Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives</title><title>Journal of biological inorganic chemistry</title><addtitle>J Biol Inorg Chem</addtitle><addtitle>J Biol Inorg Chem</addtitle><description>Two novel bis-tridentate imidazole derivatives were conveniently synthesized using a ‘one-pot’ method. Their dinuclear (Cu
2
L
1
Cl
4
, Cu
2
L
2
Cl
4
) and mononuclear (CuL
1
Cl
2
, CuL
2
Cl
2
∙H
2
O) copper (II) complexes were synthesized to comparably evaluate their reactivities in the hydrolytic cleavage of 2-hydroxypropyl p-nitrophenyl phosphate (HPNP) as a classic RNA model. Single crystals of Cu
2
L
1
Cl
4
and Cu
2
L
2
Cl
4
indicate that both of them are centrosymmetric, and each central copper ion is penta-coordinated. Regarding the transesterification of HPNP, both of dinuclear ones exhibited excess one order of magnitude rate enhancement in contrast with auto-hydrolysis reaction. Under comparable conditions, dinuclear complexes displayed no more than twofold increase in activity over their mononuclear analogues, which verifies the lack of binuclear cooperation effect due to long Cu-to-Cu space.
Graphical Abstract</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Copper</subject><subject>Crystals</subject><subject>Imidazole</subject><subject>Inorganic chemistry</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Original Paper</subject><subject>p-Nitrophenylphosphate</subject><issn>1432-1327</issn><issn>0949-8257</issn><issn>1432-1327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kcFPHCEUxompqevaf6AHQ9KLHsbCADszx41pdZONJo2eCQMPxczACDPbqv980dXW9NAD8AK_9328fAh9puSEElJ9TXmrREFKlhchpFjsoBnlrCwoK6sP7-o9tJ_SXUaYoOIj2mMV5WRRkxl6uorKJ0gjRGedVqMLHgeLf1wscR8MdNh5M2kwuH3APmzyhXF-0h2oiHUYBoj4aLU6znU_dPALEv7pxlvculSM0RnwoxoBu94Z9Rg6wCYbbbLNBtIB2rWqS_Dp9Zyj6-_frk7Pi_Xl2ep0uS40q8RYKKFaUedZuLFWCDCw4Jwzw6GllilleMtMyVhLFOGmsY1qm1JTog00YKxmc3S01R1iuJ_yrLJ3SUPXKQ9hSrKsSSM4r-smo1_-Qe_CFH3-XaY4bSra8Geq3FI6hpQiWDlE16v4ICmRz9HIbTQyRyNfopGL3HT4Kj21PZg_LW9ZZIBtgZSf_A3Ev97_kf0NUkmbkA</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Wang, Xiuyang</creator><creator>Shu, Jun</creator><creator>Ni, Tong</creator><creator>Xu, Chengxu</creator><creator>Xu, Bin</creator><creator>Liu, Xiaoqiang</creator><creator>Zhang, Kaiming</creator><creator>Jiang, Weidong</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230801</creationdate><title>Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives</title><author>Wang, Xiuyang ; Shu, Jun ; Ni, Tong ; Xu, Chengxu ; Xu, Bin ; Liu, Xiaoqiang ; Zhang, Kaiming ; Jiang, Weidong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a5ab581434dff55ede64443d4eb1f3aad4b3d233b0a04d9f9ab92c10cde9edfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Copper</topic><topic>Crystals</topic><topic>Imidazole</topic><topic>Inorganic chemistry</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Original Paper</topic><topic>p-Nitrophenylphosphate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiuyang</creatorcontrib><creatorcontrib>Shu, Jun</creatorcontrib><creatorcontrib>Ni, Tong</creatorcontrib><creatorcontrib>Xu, Chengxu</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><creatorcontrib>Liu, Xiaoqiang</creatorcontrib><creatorcontrib>Zhang, Kaiming</creatorcontrib><creatorcontrib>Jiang, Weidong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biological inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiuyang</au><au>Shu, Jun</au><au>Ni, Tong</au><au>Xu, Chengxu</au><au>Xu, Bin</au><au>Liu, Xiaoqiang</au><au>Zhang, Kaiming</au><au>Jiang, Weidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives</atitle><jtitle>Journal of biological inorganic chemistry</jtitle><stitle>J Biol Inorg Chem</stitle><addtitle>J Biol Inorg Chem</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>28</volume><issue>5</issue><spage>473</spage><epage>483</epage><pages>473-483</pages><issn>1432-1327</issn><issn>0949-8257</issn><eissn>1432-1327</eissn><abstract>Two novel bis-tridentate imidazole derivatives were conveniently synthesized using a ‘one-pot’ method. Their dinuclear (Cu
2
L
1
Cl
4
, Cu
2
L
2
Cl
4
) and mononuclear (CuL
1
Cl
2
, CuL
2
Cl
2
∙H
2
O) copper (II) complexes were synthesized to comparably evaluate their reactivities in the hydrolytic cleavage of 2-hydroxypropyl p-nitrophenyl phosphate (HPNP) as a classic RNA model. Single crystals of Cu
2
L
1
Cl
4
and Cu
2
L
2
Cl
4
indicate that both of them are centrosymmetric, and each central copper ion is penta-coordinated. Regarding the transesterification of HPNP, both of dinuclear ones exhibited excess one order of magnitude rate enhancement in contrast with auto-hydrolysis reaction. Under comparable conditions, dinuclear complexes displayed no more than twofold increase in activity over their mononuclear analogues, which verifies the lack of binuclear cooperation effect due to long Cu-to-Cu space.
Graphical Abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37140680</pmid><doi>10.1007/s00775-023-02000-6</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of biological inorganic chemistry, 2023-08, Vol.28 (5), p.473-483 |
| issn | 1432-1327 0949-8257 1432-1327 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2809544889 |
| source | Springer Nature |
| subjects | Biochemistry Biomedical and Life Sciences Copper Crystals Imidazole Inorganic chemistry Life Sciences Microbiology Original Paper p-Nitrophenylphosphate |
| title | Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives |
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