Systematic parallel investigation of RAFT polymerizations for eight different (meth)acrylates: A basis for the designed synthesis of block and random copolymers

• Published in: Journal of polymer science. Part A, Polymer chemistry Polymer chemistry, 2005-09, Vol.43 (17), p.3831-3839
• Main Authors: Fijten, Martin W. M., Paulus, Renzo M., Schubert, Ulrich S.
• Format: Article
• Language: English
• Subjects: acrylates; Applied sciences; block copolymers; Exact sciences and technology; high-throughput experimentation; methacrylates; Organic polymers; parallel chemistry; Physicochemistry of polymers; Polymerization; Preparation, kinetics, thermodynamics, mechanism and catalysts; random copolymers; reversible addition-fragmentation chain transfer polymerization
• ISSN: 0887-624X; 1099-0518
• DOI: 10.1002/pola.20868

Poly(acrylate)s as well as poly(methacrylate)s were successfully synthesized via reversible addition‐fragmentation chain‐transfer (RAFT) polymerizations using 2‐cyano‐2‐butyl dithiobenzoate (CBDB) as RAFT‐agent. Four different ratios of RAFT to initiator were screened for four acrylates and four methacrylates using automated parallel synthesizer robots. The reactions were monitored by gel permeation chromatography (GPC) and gas chromatography (GC). The knowledge obtained during this screening was used for the designed synthesis of block and random copolymers containing a water‐ and a non water‐soluble monomer. The results obtained from GPC analysis together with 1H NMR spectroscopy demonstrate the possibility to design and prepare well‐defined block and random copolymers. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 3831–3839, 2005 The successful polymerized acrylates (right top) and methacrylates (left bottom) via RAFT polymerization using 2‐cyano‐2‐butyl dithiobenzoate as RAFT‐agent are displayed.