Fatal rupture of hepatic adenomatosis: Autopsy case and review of the literature

Hepatic adenomatosis is a rare disease consisting of multiple adenomas in otherwise‐normal liver parenchyma. Though the discovery of this entity goes back several years, its diagnosis is still challenging in terms of its definition and pathophysiology. Clinically, patients may be completely asymptom...

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Bibliographic Details
Published in:Journal of forensic sciences 2023-07, Vol.68 (4), p.1393-1400
Main Authors: Ben Abderrahim, Sarra, Chérif, Khouloud, Nfikha, Zeineb, Gharsallaoui, Sarra, El Aini, Imen, Jedidi, Maher, Mokni, Moncef, Ben Dhiab, Mohamed
Format: Article
Language:English
Subjects:
Autopsies
autopsy
Diagnosis
forensic pathology
Hemorrhage
hemorrhagic rupture
hepatic adenoma
hepatic adenomatosis
hepatocellular adenoma
Literature reviews
Pathogenesis
Rupturing
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Summary:Hepatic adenomatosis is a rare disease consisting of multiple adenomas in otherwise‐normal liver parenchyma. Though the discovery of this entity goes back several years, its diagnosis is still challenging in terms of its definition and pathophysiology. Clinically, patients may be completely asymptomatic and the diagnosis is only made incidentally through imaging tests. The discovery could be made when complications occur such as intraperitoneal hemorrhage with hypovolemic shock due to the rupture of an adenoma. We report a fatal case of a ruptured adenoma in a case of hepatic adenomatosis discovered at autopsy. In order to achieve a better view of this disease, we conducted a literature review on this subject describing the pathogenesis, manifestations, and autopsy contribution to addressing this entity.
ISSN:0022-1198
1556-4029
DOI:10.1111/1556-4029.15272