Galectins are critical regulators of cytokine signalling at feto-maternal interface in infection-associated spontaneous preterm birth

Spontaneous preterm birth (sPTB) is a global health issue. Studies suggest infections are chiefly associated with sPTB and galectins (gals) play a role in regulation of innate and adaptive maternal immune response against pathogens during sPTB. The aim of this study was to describe the gene expressi...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2023-07, Vol.138, p.10-19
Main Authors: Bhati, Tanu, Ray, Ankita, Arora, Renu, Siraj, Fouzia, Parvez, Suhel, Rastogi, Sangita
Format: Article
Language:English
Subjects:
Chlamydia trachomatis
Cyclooxygenase 2
Cytokines
Female
Galectins
Humans
Infant, Newborn
Interleukin-10
Interleukin-8
Mycoplasma hominis
Placenta
Pregnancy
Premature Birth
Preterm birth
Tumor Necrosis Factor-alpha
Ureaplasma urealyticum
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Summary:Spontaneous preterm birth (sPTB) is a global health issue. Studies suggest infections are chiefly associated with sPTB and galectins (gals) play a role in regulation of innate and adaptive maternal immune response against pathogens during sPTB. The aim of this study was to describe the gene expression of gal -1, -3, -8, -9, -13 in relation to gene expression of cyclooxygenase-2 (COX-2) and the cytokines IL-8, IL-10, TNF-α, IFN-ϒ in the setting of sPTB and confirmed infection with Chlamydia trachomatis, Mycoplasma hominis, and Ureaplasma urealyticum. Placental samples were collected from 120 term control and 120 sPTB pregnancies. PCR was used to detect specific pathogens. Gene expression of galectins, cytokines, and COX-2 was performed using real time qPCR. Fold-change expression of gal -1, -3, -8, -9, -13 was 5.13, 6.11, 1.14, 5.23 and 7.16 (p
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2023.04.015