Value of contrast-enhanced MR angiography for the follow-up of treated brain arteriovenous malformations: systematic review and meta-analysis

• Published in: European radiology 2023-10, Vol.33 (10), p.7139-7148
• Main Authors: Zhuo, Yudi, Chang, Jingling, Chen, Yi, Wen, Chunli, Chen, Fei, Li, Wenhui, Gao, Mengxia, Luo, Weibo, Wan, Shurun, Song, Lianying, Zhu, Lingqun
• Format: Article
• Language: English
• Subjects: Angiography; Bias; Bivariate analysis; Brain; Diagnostic Radiology; Heterogeneity; Imaging; Internal Medicine; Interventional Radiology; Medical imaging; Medicine; Medicine & Public Health; Meta-analysis; Neuroradiology; Radiology; Regression analysis; Review; Sensitivity; Ultrasound
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-023-09714-w

Objective To estimate the diagnostic value of contrast-enhanced MR angiography (CE-MRA) in identifying residual brain arteriovenous malformations (AVMs) after treatment. Methods We retrieved appropriate references from the electronic databases of PubMed, Web of Science, Embase, and Cochrane Library, and then evaluated the methodology quality of included references using the QUADAS-2 tool. We calculated the pooled sensitivity and specificity by applying a bivariate mixed-effects model and detected the publication bias using Deeks’ funnel plot. The values of I 2 were used to test heterogeneity and meta-regression analyses were performed to search for the causes of heterogeneity. Results We included 7 eligible studies containing 223 participants. Compared with a gold standard, the overall sensitivity and specificity of CE-MRA in detecting residual brain AVMs were 0.77 (95% CI 0.65–0.86) and 0.97 (95% CI 0.82–1.00), respectively. Based on the summary ROC curve, the AUC was 0.89 (95% CI 0.86–0.92). Heterogeneity could be observed in our study, especially for the specificity ( I 2 = 74.23%). Furthermore, there was no evidence of publication bias. Conclusions Our study provides evidence that CE-MRA has good diagnostic value and specificity for the follow-up of treated brain AVMs. Nevertheless, considering the small sample size, heterogeneity, and many factors that may affect the diagnostic accuracy, future large-sample, prospective studies are necessary to validate the results. Key Points • The pooled sensitivity and specificity of contrast-enhanced MR angiography (CE-MRA) in detecting residual arteriovenous malformations (AVMs) were 0.77 (95% CI 0.65–0.86) and 0.97 (95% CI 0.82–1.00). • The four-dimensional CE-MRA showed less sensitivity than the three-dimensional CE-MRA for treated AVMs. • CE-MRA is helpful to identify residual AVMs and reduce excessive DSA during follow-up.