Muscle velocity recovery cycles in myopathy

•Muscle velocity recovery cycles (MVRC), frequency ramp and EMG were performed on 42 patients with myopathy and 42 healthy controls.•MVRC and frequency ramp measures differed from controls in the non-inflammatory myopathy patients but not in inflammatory myopathy.•MVRC with frequency ramp may be a u...

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Published in:Clinical neurophysiology 2023-07, Vol.151, p.41-49
Main Authors: Meldgaard, M., Kristensen, R.S., Z'Graggen, W.J., Tan, S.V., Søndergaard, K., Qerama, E., Andersen, H., Fuglsang-Frederiksen, A., Tankisi, H.
Format: Article
Language:English
Subjects:
Electromyography
Frequency ramp
Humans
Inflammatory myopathy
Membrane Potentials
Muscle Contraction - physiology
Muscle velocity recovery cycles
Muscle, Skeletal
Muscular Diseases
Non-inflammatory myopathy
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Summary:•Muscle velocity recovery cycles (MVRC), frequency ramp and EMG were performed on 42 patients with myopathy and 42 healthy controls.•MVRC and frequency ramp measures differed from controls in the non-inflammatory myopathy patients but not in inflammatory myopathy.•MVRC with frequency ramp may be a useful method for detection of abnormal membrane properties in myopathy of broad aetiology. To understand the pathophysiology of myopathies by using muscle velocity recovery cycles (MVRC) and frequency ramp (RAMP) methodologies. 42 patients with quantitative electromyography (qEMG) and biopsy or genetic verified myopathy and 42 healthy controls were examined with qEMG, MVRC and RAMP, all recorded from the anterior tibial muscle. There were significant differences in the motor unit potential (MUP) duration, the early and late supernormalities of the MVRC and the RAMP latencies in myopathy patients compared to controls (p 
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2023.04.001