Ovaries of guppies (Poecilia reticulata) investigated in pre-embryonic, embryonic and post-embryonic stages after exposure to maghemite nanoparticles (y-Fe2O3) associated with Roundup® and glyphosate, followed by recovery period evaluation

Iron oxide nanoparticles (IONP) are promising alternatives to environmental remediation, so this study investigates IONP single and associated to contaminants, in this case, glyphosate (GLY) and Roundup® (GBH) in Poecilia reticulata (guppy). The guppies have internal development, therefore this stud...

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Published in:Environmental toxicology and pharmacology 2023-06, Vol.100, p.104144-104144, Article 104144
Main Authors: Silva, Victória Costa da, Lima-Faria, João Marcos de, Guimarães, Lucas Nunes, Costa, Matheus Santos, Lima, Phâmella Neres de, Simões, Karina, Jesus, Lázaro Wender Oliveira de, Sabóia-Morais, Simone Maria Teixeira de
Format: Article
Language:English
Subjects:
Animals
Environmental health
Female
Glyphosate
Intra-ovarian development
Liver
Magnetic Iron Oxide Nanoparticles
Nanotechnology
Ovary
Pesticide
Poecilia
Remediation
Teratogenesis
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Summary:Iron oxide nanoparticles (IONP) are promising alternatives to environmental remediation, so this study investigates IONP single and associated to contaminants, in this case, glyphosate (GLY) and Roundup® (GBH) in Poecilia reticulata (guppy). The guppies have internal development, therefore this study analyzed female gonads to establish the developmental stages of P. reticulata and evaluate effects of exposure (7, 14 and 21 days) and post-exposure (same period) to the treatments with Iron ions 0.3 mg Fe/L (IFe); IONP 0.3 mg Fe/L; IONP 0.3 mgFe/L + GBH 0,65 mgGLY/L (IONP+GBH1); IONP 0.3 mgFe/L + GBH 1.30 mgGLY/L (IONP+GBH2); and IONP 0.3 mgFe/L + GLY 0.65 mg/L (IONP+GLY). The development was organized in immature, development, and gestation phases. The damage in all treatments after 21 days of exposure was evident in reaction patterns regressive inflammatory, and circulatory including total histopathologic index of liver, nevertheless there was a damage recovery trend during post-exposure period. [Display omitted] •Co-exposure to IONPs and glyphosate cause reproductive toxicity starting at 7 days of exposure.•Histopathological changes are time-treatment dependent.•The most recurrent reproductive changes were follicular atresia and follicular degeneration.•There is a trend towards recovery in animals exposed to IONPs and glyphosate.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2023.104144