Commensal Bacillus siamensis LF4 ameliorates β-conglycinin induced inflammation in intestinal epithelial cells of Lateolabrax maculatus

β-conglycinin and glycinin, two major heat-stable anti-nutritional factors in soybean meal (SM), have been suggested as the key inducers of intestinal inflammation in aquatic animals. In the present study, a spotted seabass intestinal epithelial cells (IECs) were used to compare the inflammation-ind...

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Bibliographic Details
Published in:Fish & shellfish immunology 2023-06, Vol.137, p.108797-108797, Article 108797
Main Authors: Liu, Zi-Yan, Yang, Hong-Ling, Ding, Xi-Yue, Li, Sha, Cai, Guo-He, Ye, Ji-Dan, Zhang, Chun-Xiao, Sun, Yun-Zhang
Format: Article
Language:English
Subjects:
Animals
Bacillus siamensis
Caspase 3 - metabolism
Caspase 8
Caspase 9
Epithelial Cells - metabolism
Glycinin
Inflammation
Inflammation - chemically induced
Inflammation - metabolism
Inflammation - veterinary
Interleukin-10 - metabolism
Interleukin-2
Interleukin-4 - metabolism
Interleukin-8
Intestinal epithelial cells
Lateolabrax maculatus
Soybean Proteins - adverse effects
Transforming Growth Factor beta1 - metabolism
Tumor Necrosis Factor-alpha - metabolism
β-conglycinin
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Summary:β-conglycinin and glycinin, two major heat-stable anti-nutritional factors in soybean meal (SM), have been suggested as the key inducers of intestinal inflammation in aquatic animals. In the present study, a spotted seabass intestinal epithelial cells (IECs) were used to compare the inflammation-inducing effects of β-conglycinin and glycinin. The results showed that IECs co-cultured with 1.0 mg/mL β-conglycinin for 12 h or 1.5 mg/mL glycinin for 24 h significantly decreased the cell viability (P 
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2023.108797