Association of multiple air pollutants with oxygen saturation during sleep in COPD patients: Effect modification by smoking status and airway inflammatory phenotypes

• Published in: Journal of hazardous materials 2023-07, Vol.454, p.131550-131550, Article 131550
• Main Authors: Zhang, Wenlou, Wang, Junyi, Chen, Baiqi, Ji, Xuezhao, Zhao, Chen, Chen, Maike, Liao, Sha, Jiang, Simin, Pan, Zihan, Wang, Wanzhou, Li, Luyi, Chen, Yahong, Guo, Xinbiao, Deng, Furong
• Format: Article
• Language: English
• Subjects: Air Pollutants - analysis; Air pollution; Air Pollution - analysis; Airway inflammation; Chronic obstructive pulmonary disease; Environmental Exposure - analysis; Humans; Oxygen Saturation; Ozone - analysis; Particulate Matter - analysis; Phenotype; Pulmonary Disease, Chronic Obstructive - chemically induced; Pulmonary Disease, Chronic Obstructive - epidemiology; Smoking; Smoking - adverse effects
• ISSN: 0304-3894; 1873-3336
• DOI: 10.1016/j.jhazmat.2023.131550

Air pollution contributes substantially to the development of chronic obstructive pulmonary disease (COPD). To date, the effect of air pollution on oxygen saturation (SpO2) during sleep and potential susceptibility factors remain unknown. In this longitudinal panel study, real-time SpO2 was monitored in 132 COPD patients, with 270 nights (1615 h) of sleep SpO2 recorded. Exhaled nitric oxide (NO), hydrogen sulfide (H2S) and carbon monoxide (CO) were measured to assess airway inflammatory characteristics. Exposure levels of air pollutants were estimated by infiltration factor method. Generalized estimating equation was used to investigate the effect of air pollutants on sleep SpO2. Ozone, even at low levels (