Strongly adhesive zwitterionic composite hydrogel paints for surgical sutures and blood-contacting devices

• Published in: Acta biomaterialia 2023-08, Vol.166, p.201-211
• Main Authors: Yao, Mengmeng, Yan, Zhuojun, Sun, Xia, Guo, Bingyan, Yu, Chaojie, Zhao, Zhongming, Li, Xi, Tan, Zhouying, Zhang, Hong, Yao, Fanglian, Li, Junjie
• Format: Article
• Language: English
• Subjects: Adhesives; Animals; Anti-thrombogenicity; Biofouling - prevention & control; Biomedical devices; Hydrogel paints; Hydrogels - chemistry; Hydrogels - pharmacology; Microgels; Non-fouling; Polymers - chemistry; Rabbits; Surface modifications; Zwitterions
• ISSN: 1742-7061; 1878-7568
• DOI: 10.1016/j.actbio.2023.05.003

Hydrogels show eminent advantages in biomedical and pharmaceutical fields. However, their application as coating materials for biomedical devices is limited by several key challenges, such as lack of universality, weak mechanical strength, and low adhesion to the substrate. Here we report versatile and tough adhesion composite hydrogel paints (CHPs), which consist of zwitterionic copolymers and microgels, both with reactive groups. The CHPs exhibit tunable rheology and thickness, hydrophilicity, biofouling resistance, durability, and convenient fabrication on metal, polymer, and inorganic surfaces with arbitrary shapes. As a proof-of-concept, the CHP-surgical sutures demonstrate exceptional lubrication, drug delivery, anti-infection, and anti-fibrous capsule properties. Moreover, the CHP-PVC tubing effectively prevents thrombus formation in vitro and ex vivo rabbit blood circulation without anticoagulants. This work provides valuable insights for enhancing and developing integrated hydrogel technologies for biomedical devices. The combination of hydrogel and biomedical devices can enable numerous existing applications in medicine. In this study, inspired by the principle of microgel reinforcement in industrial paints, we propose a simple and versatile zwitterionic composite hydrogel paints (CHPs) strategy, which can be easily applied to diverse substrates with arbitrary shapes by covalent grafting between complementary groups by brush, dip, or spray. The CHPs integrated universality, tough adhesion, mechanical durability, and anti-biofouling properties because of their unique chemical composition and coating structure design. This strategy provides a simple and versatile route for surface modification of biomedical devices. [Display omitted]