Natural Geranylated Sulfur‐Containing Amides with Inhibitory Effect on Th17 Differentiation

Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1–10), including two previously unreported geranylated sulfur‐containing amides (1 and 2) and eight known ones (3–10). Structural characterization was carried out using comp...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-06, Vol.20 (6), p.e202300373-n/a
Main Authors: Ji, Kai‐Long, Tang, Yan‐Qing, Guo, Zheng‐Yang, GongPan, Pian‐Chou, Sun, Peng, Lu, Jian‐Mei, Dai, Meng‐Yuan, Li, Ting
Format: Article
Language:English
Subjects:
Amides
Differentiation
geranylated sulfonyl amides
Glycosmis lucida
glylucidamides
Helper cells
Herbal medicine
Lymphocytes T
Medicinal plants
NMR
Nuclear magnetic resonance
Retinoic acid
RORγt
Structural analysis
Sulfur
Th17 differentiation
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Summary:Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1–10), including two previously unreported geranylated sulfur‐containing amides (1 and 2) and eight known ones (3–10). Structural characterization was carried out using comprehensive spectroscopic methods including NMR, MS and CD. The inhibitory effects of all isolates on Th17 differentiation were evaluated, of which compounds 1 and 6 significantly inhibited Th17 differentiation with IC50 values of 0.36 and 1.30 μM, respectively, while both 1 and 6 failed to bind to retinoic acid‐related orphan receptor gamma t (RORγt), suggesting that their inhibition of Th17 differentiation is independent of RORγt.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300373