Leukoreduction as a control measure in transfusion transmission of visceral leishmaniasis

Background Asymptomatic visceral leishmaniasis (VL) infection is a risk for transfusion safety. Leukoreduction has been an alternative for the prevention of some blood‐borne diseases, including VL. This study aimed to evaluate the role of leukoreduction of cellular blood components as a control meas...

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Published in:Transfusion (Philadelphia, Pa.) Pa.), 2023-05, Vol.63 (5), p.1044-1049
Main Authors: Pereira, Loren Queli, Tanaka, Sarah Cristina Sato Vaz, Ferreira‐Silva, Márcia Maria, Gomes, Francisca Vânia Barreto Aguiar Ferreira, Santana, Melissa Palis, Aguiar, Paulo Roberto, Araújo Pereira, Gilberto, Gómez‐Hernández, César, Junior, Virmondes Rodrigues, De Vito, Fernanda Bernadelli, Moraes‐Souza, Helio
Format: Article
Language:English
Subjects:
Antibodies
asymptomatic infection
Asymptomatic Infections
Blood
blood transfusion
Enzyme-Linked Immunosorbent Assay
Epidemiology
Health risks
Humans
Leishmania infantum
leishmaniasis visceral
Leishmaniasis, Visceral - epidemiology
Leishmaniasis, Visceral - prevention & control
leukodepletion filter
Parasites
Parasitic diseases
Prevention
Real-Time Polymerase Chain Reaction
Research design
Statistical analysis
Transfusion
Vector-borne diseases
Visceral leishmaniasis
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Summary:Background Asymptomatic visceral leishmaniasis (VL) infection is a risk for transfusion safety. Leukoreduction has been an alternative for the prevention of some blood‐borne diseases, including VL. This study aimed to evaluate the role of leukoreduction of cellular blood components as a control measure for transfusional VL transmission. Research Design and Methods A total of 161 polytransfused patients with non‐leukoreduced blood components (HNL), 95 polytransfused with leukoreduced blood components (LH), and 202 non‐transfused (NT) from endemic regions for VL and with a similar epidemiological profile. The detection of antibodies against VL was performed by ELISA and the presence of the parasite was investigated by real‐time PCR. Statistical significance was defined as p 
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.17308