Cuproptosis‐Inducible Chemotherapeutic/Cascade Catalytic Reactor System for Combating with Breast Cancer

Cascade hydroxyl radical generating hydrogel reactor structures including a chemotherapeutic agent are invented for multiple treatment of breast cancer. Glucose oxidase (GOx) and cupric sulfate (Cu) are introduced for transforming accumulated glucose (in cancer cells) to hydroxyl radicals for starva...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2023-08, Vol.19 (35), p.e2301402-n/a
Main Authors: Lee, Song Yi, Seo, Ji‐Hye, Kim, Sungyun, Hwang, ChaeRim, Jeong, Da In, Park, JiHye, Yang, Mingyu, Huh, Ji Won, Cho, Hyun‐Jong
Format: Article
Language:English
Subjects:
Breast cancer
Catechol
Cell death
chemodynamic therapy
chemotherapy
cuproptosis
Dopamine
Fenton‐like reaction
Glucose oxidase
Hyaluronic acid
hydrogel
Hydrogels
Hydroxyl radicals
Nanotechnology
Viscoelasticity
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Summary:Cascade hydroxyl radical generating hydrogel reactor structures including a chemotherapeutic agent are invented for multiple treatment of breast cancer. Glucose oxidase (GOx) and cupric sulfate (Cu) are introduced for transforming accumulated glucose (in cancer cells) to hydroxyl radicals for starvation/chemodynamic therapy. Cu may also suppress cancer cell growth via cuproptosis‐mediated cell death. Berberine hydrochloride (BER) is engaged as a chemotherapeutic agent in the hydrogel reactor for combining with starvation/chemodynamic/cuproptosis therapeutic modalities. Moreover, Cu is participated as a gel crosslinker by coordinating with catechol groups in hyaluronic acid‐dopamine (HD) polymer. Controlling viscoelasticity of hydrogel reactor can extend the retention time following local injection and provide sustained drug release patterns. Low biodegradation rate of designed HD/BER/GOx/Cu hydrogel can reduce dosing frequency in local cancer therapy and avoid invasiveness‐related inconveniences. Especially, it is anticipated that HD/BER/GOx/Cu hydrogel system can be applied for reducing size of breast cancer prior to surgery as well as tumor growth suppression in clinical application. Cuproptosis‐inducible hydrogel reactor system equipped with chemo/starvation/chemodynamic modalities is designed for localized breast cancer therapy. Local injection of crosslinked hyaluronic acid hydrogel system to breast cancer region efficiently suppressed the growth of primary tumor and its recurrence by multiple therapeutic mechanisms (e.g., cuproptosis, glucose deprivation, ROS generation, and antiproliferation).
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202301402