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Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study
Background Some oral squamous cell carcinoma (OSCC) cases are unaffected by smoking or drinking. This study aimed to clarify distinctive groups among OSCC patients and examine the characteristics of multiple primary carcinomas (MPCs). Methods We analyzed data from 970 patients. The patients were div...
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| Published in: | Head & neck 2023-07, Vol.45 (7), p.1812-1822 |
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| container_end_page | 1822 |
| container_issue | 7 |
| container_start_page | 1812 |
| container_title | Head & neck |
| container_volume | 45 |
| creator | Harada, Hiroyuki Kikuchi, Masahiro Asato, Ryo Hamaguchi, Kiyomi Tamaki, Hisanobu Mizuta, Masanobu Hori, Ryusuke Kojima, Tsuyoshi Honda, Keigo Tsujimura, Takashi Kumabe, Yohei Ichimaru, Kazuyuki Kitani, Yoshiharu Ushiro, Koji Kitamura, Morimasa Shinohara, Shogo Omori, Koichi |
| description | Background
Some oral squamous cell carcinoma (OSCC) cases are unaffected by smoking or drinking. This study aimed to clarify distinctive groups among OSCC patients and examine the characteristics of multiple primary carcinomas (MPCs).
Methods
We analyzed data from 970 patients. The patients were divided into three groups: all individuals |
| doi_str_mv | 10.1002/hed.27398 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2811940801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2822955886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4198-5574fa778e49540b47131f470d9872079167cfbf10232888c09cdd17fbe3a53a3</originalsourceid><addsrcrecordid>eNp1kU1PHSEUhomxqR_ton_AkLjRxejhYy7gztza2sSkm3Y9YRhQ7AxcYdDcX9C_XaZXN026Ag4Pz-HkRegTgQsCQC8f7HBBBVNyDx0SUKIBxsX-suesYSD4ATrK-REA2IrT9-iACbIiUsIh-r1-0Emb2SafZ28yjg7HpEecn4qeYsnY2HHERifjQ5w0dtGU7MM9jqFWs824BO2crYoB91ucp_hrudZhwEPyYTlc4Ws8lbH6baidcLJzinlT3_hni_Nchu0H9M7pMduPr-sx-vnl5sf6trn7_vXb-vquMZwo2bSt4E4LIS1XLYeeC8KI4wIGJQUFochKGNc7ApRRKaUBZYaBCNdbplum2TE623k3KT4Vm-du8nkZUQdbp-2oJERxkEAqevoP-hhLCvV3laJUta2Uq0qd7yhTR8rJum6T_KTTtiPQLel0NZ3ubzqVPXk1ln6q1TfyLY4KXO6AFz_a7f9N3e3N553yDzQOmgs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2822955886</pqid></control><display><type>article</type><title>Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Harada, Hiroyuki ; Kikuchi, Masahiro ; Asato, Ryo ; Hamaguchi, Kiyomi ; Tamaki, Hisanobu ; Mizuta, Masanobu ; Hori, Ryusuke ; Kojima, Tsuyoshi ; Honda, Keigo ; Tsujimura, Takashi ; Kumabe, Yohei ; Ichimaru, Kazuyuki ; Kitani, Yoshiharu ; Ushiro, Koji ; Kitamura, Morimasa ; Shinohara, Shogo ; Omori, Koichi</creator><creatorcontrib>Harada, Hiroyuki ; Kikuchi, Masahiro ; Asato, Ryo ; Hamaguchi, Kiyomi ; Tamaki, Hisanobu ; Mizuta, Masanobu ; Hori, Ryusuke ; Kojima, Tsuyoshi ; Honda, Keigo ; Tsujimura, Takashi ; Kumabe, Yohei ; Ichimaru, Kazuyuki ; Kitani, Yoshiharu ; Ushiro, Koji ; Kitamura, Morimasa ; Shinohara, Shogo ; Omori, Koichi</creatorcontrib><description>Background
Some oral squamous cell carcinoma (OSCC) cases are unaffected by smoking or drinking. This study aimed to clarify distinctive groups among OSCC patients and examine the characteristics of multiple primary carcinomas (MPCs).
Methods
We analyzed data from 970 patients. The patients were divided into three groups: all individuals <45 years (<45 y), smokers/drinkers ≥45 years (SD ≥45 y), and non‐smokers/non‐drinkers ≥45 years (NSND ≥45 y).
Results
Tongue cancers were more common in the <45 y group than in the other groups (p < 0.001). The NSND ≥45 y group was significantly older and more likely to be female than the SD ≥45 y group (p < 0.001). MPCs in the upper aerodigestive tract were more common in men and smokers/drinkers, whereas women were at risk for multiple primary OSCCs (p = 0.022).
Conclusions
The “young tongue” and “elderly female” subgroups and characteristics of MPCs suggest carcinogenic factors of OSCC other than smoking and drinking.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27398</identifier><identifier>PMID: 37161880</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>multiple primary carcinomas ; non‐drinker ; non‐smoker ; Oral cancer ; Oral carcinoma ; Oral squamous cell carcinoma ; Smoking ; Squamous cell carcinoma ; survival ; Tongue</subject><ispartof>Head & neck, 2023-07, Vol.45 (7), p.1812-1822</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4198-5574fa778e49540b47131f470d9872079167cfbf10232888c09cdd17fbe3a53a3</citedby><cites>FETCH-LOGICAL-c4198-5574fa778e49540b47131f470d9872079167cfbf10232888c09cdd17fbe3a53a3</cites><orcidid>0000-0002-1794-2091 ; 0000-0001-7138-8004 ; 0000-0002-0711-468X ; 0000-0002-6456-9656 ; 0000-0002-6241-4175</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37161880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harada, Hiroyuki</creatorcontrib><creatorcontrib>Kikuchi, Masahiro</creatorcontrib><creatorcontrib>Asato, Ryo</creatorcontrib><creatorcontrib>Hamaguchi, Kiyomi</creatorcontrib><creatorcontrib>Tamaki, Hisanobu</creatorcontrib><creatorcontrib>Mizuta, Masanobu</creatorcontrib><creatorcontrib>Hori, Ryusuke</creatorcontrib><creatorcontrib>Kojima, Tsuyoshi</creatorcontrib><creatorcontrib>Honda, Keigo</creatorcontrib><creatorcontrib>Tsujimura, Takashi</creatorcontrib><creatorcontrib>Kumabe, Yohei</creatorcontrib><creatorcontrib>Ichimaru, Kazuyuki</creatorcontrib><creatorcontrib>Kitani, Yoshiharu</creatorcontrib><creatorcontrib>Ushiro, Koji</creatorcontrib><creatorcontrib>Kitamura, Morimasa</creatorcontrib><creatorcontrib>Shinohara, Shogo</creatorcontrib><creatorcontrib>Omori, Koichi</creatorcontrib><title>Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Some oral squamous cell carcinoma (OSCC) cases are unaffected by smoking or drinking. This study aimed to clarify distinctive groups among OSCC patients and examine the characteristics of multiple primary carcinomas (MPCs).
Methods
We analyzed data from 970 patients. The patients were divided into three groups: all individuals <45 years (<45 y), smokers/drinkers ≥45 years (SD ≥45 y), and non‐smokers/non‐drinkers ≥45 years (NSND ≥45 y).
Results
Tongue cancers were more common in the <45 y group than in the other groups (p < 0.001). The NSND ≥45 y group was significantly older and more likely to be female than the SD ≥45 y group (p < 0.001). MPCs in the upper aerodigestive tract were more common in men and smokers/drinkers, whereas women were at risk for multiple primary OSCCs (p = 0.022).
Conclusions
The “young tongue” and “elderly female” subgroups and characteristics of MPCs suggest carcinogenic factors of OSCC other than smoking and drinking.</description><subject>multiple primary carcinomas</subject><subject>non‐drinker</subject><subject>non‐smoker</subject><subject>Oral cancer</subject><subject>Oral carcinoma</subject><subject>Oral squamous cell carcinoma</subject><subject>Smoking</subject><subject>Squamous cell carcinoma</subject><subject>survival</subject><subject>Tongue</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kU1PHSEUhomxqR_ton_AkLjRxejhYy7gztza2sSkm3Y9YRhQ7AxcYdDcX9C_XaZXN026Ag4Pz-HkRegTgQsCQC8f7HBBBVNyDx0SUKIBxsX-suesYSD4ATrK-REA2IrT9-iACbIiUsIh-r1-0Emb2SafZ28yjg7HpEecn4qeYsnY2HHERifjQ5w0dtGU7MM9jqFWs824BO2crYoB91ucp_hrudZhwEPyYTlc4Ws8lbH6baidcLJzinlT3_hni_Nchu0H9M7pMduPr-sx-vnl5sf6trn7_vXb-vquMZwo2bSt4E4LIS1XLYeeC8KI4wIGJQUFochKGNc7ApRRKaUBZYaBCNdbplum2TE623k3KT4Vm-du8nkZUQdbp-2oJERxkEAqevoP-hhLCvV3laJUta2Uq0qd7yhTR8rJum6T_KTTtiPQLel0NZ3ubzqVPXk1ln6q1TfyLY4KXO6AFz_a7f9N3e3N553yDzQOmgs</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Harada, Hiroyuki</creator><creator>Kikuchi, Masahiro</creator><creator>Asato, Ryo</creator><creator>Hamaguchi, Kiyomi</creator><creator>Tamaki, Hisanobu</creator><creator>Mizuta, Masanobu</creator><creator>Hori, Ryusuke</creator><creator>Kojima, Tsuyoshi</creator><creator>Honda, Keigo</creator><creator>Tsujimura, Takashi</creator><creator>Kumabe, Yohei</creator><creator>Ichimaru, Kazuyuki</creator><creator>Kitani, Yoshiharu</creator><creator>Ushiro, Koji</creator><creator>Kitamura, Morimasa</creator><creator>Shinohara, Shogo</creator><creator>Omori, Koichi</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1794-2091</orcidid><orcidid>https://orcid.org/0000-0001-7138-8004</orcidid><orcidid>https://orcid.org/0000-0002-0711-468X</orcidid><orcidid>https://orcid.org/0000-0002-6456-9656</orcidid><orcidid>https://orcid.org/0000-0002-6241-4175</orcidid></search><sort><creationdate>202307</creationdate><title>Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study</title><author>Harada, Hiroyuki ; Kikuchi, Masahiro ; Asato, Ryo ; Hamaguchi, Kiyomi ; Tamaki, Hisanobu ; Mizuta, Masanobu ; Hori, Ryusuke ; Kojima, Tsuyoshi ; Honda, Keigo ; Tsujimura, Takashi ; Kumabe, Yohei ; Ichimaru, Kazuyuki ; Kitani, Yoshiharu ; Ushiro, Koji ; Kitamura, Morimasa ; Shinohara, Shogo ; Omori, Koichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4198-5574fa778e49540b47131f470d9872079167cfbf10232888c09cdd17fbe3a53a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>multiple primary carcinomas</topic><topic>non‐drinker</topic><topic>non‐smoker</topic><topic>Oral cancer</topic><topic>Oral carcinoma</topic><topic>Oral squamous cell carcinoma</topic><topic>Smoking</topic><topic>Squamous cell carcinoma</topic><topic>survival</topic><topic>Tongue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harada, Hiroyuki</creatorcontrib><creatorcontrib>Kikuchi, Masahiro</creatorcontrib><creatorcontrib>Asato, Ryo</creatorcontrib><creatorcontrib>Hamaguchi, Kiyomi</creatorcontrib><creatorcontrib>Tamaki, Hisanobu</creatorcontrib><creatorcontrib>Mizuta, Masanobu</creatorcontrib><creatorcontrib>Hori, Ryusuke</creatorcontrib><creatorcontrib>Kojima, Tsuyoshi</creatorcontrib><creatorcontrib>Honda, Keigo</creatorcontrib><creatorcontrib>Tsujimura, Takashi</creatorcontrib><creatorcontrib>Kumabe, Yohei</creatorcontrib><creatorcontrib>Ichimaru, Kazuyuki</creatorcontrib><creatorcontrib>Kitani, Yoshiharu</creatorcontrib><creatorcontrib>Ushiro, Koji</creatorcontrib><creatorcontrib>Kitamura, Morimasa</creatorcontrib><creatorcontrib>Shinohara, Shogo</creatorcontrib><creatorcontrib>Omori, Koichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harada, Hiroyuki</au><au>Kikuchi, Masahiro</au><au>Asato, Ryo</au><au>Hamaguchi, Kiyomi</au><au>Tamaki, Hisanobu</au><au>Mizuta, Masanobu</au><au>Hori, Ryusuke</au><au>Kojima, Tsuyoshi</au><au>Honda, Keigo</au><au>Tsujimura, Takashi</au><au>Kumabe, Yohei</au><au>Ichimaru, Kazuyuki</au><au>Kitani, Yoshiharu</au><au>Ushiro, Koji</au><au>Kitamura, Morimasa</au><au>Shinohara, Shogo</au><au>Omori, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2023-07</date><risdate>2023</risdate><volume>45</volume><issue>7</issue><spage>1812</spage><epage>1822</epage><pages>1812-1822</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Some oral squamous cell carcinoma (OSCC) cases are unaffected by smoking or drinking. This study aimed to clarify distinctive groups among OSCC patients and examine the characteristics of multiple primary carcinomas (MPCs).
Methods
We analyzed data from 970 patients. The patients were divided into three groups: all individuals <45 years (<45 y), smokers/drinkers ≥45 years (SD ≥45 y), and non‐smokers/non‐drinkers ≥45 years (NSND ≥45 y).
Results
Tongue cancers were more common in the <45 y group than in the other groups (p < 0.001). The NSND ≥45 y group was significantly older and more likely to be female than the SD ≥45 y group (p < 0.001). MPCs in the upper aerodigestive tract were more common in men and smokers/drinkers, whereas women were at risk for multiple primary OSCCs (p = 0.022).
Conclusions
The “young tongue” and “elderly female” subgroups and characteristics of MPCs suggest carcinogenic factors of OSCC other than smoking and drinking.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>37161880</pmid><doi>10.1002/hed.27398</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1794-2091</orcidid><orcidid>https://orcid.org/0000-0001-7138-8004</orcidid><orcidid>https://orcid.org/0000-0002-0711-468X</orcidid><orcidid>https://orcid.org/0000-0002-6456-9656</orcidid><orcidid>https://orcid.org/0000-0002-6241-4175</orcidid></addata></record> |
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| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2023-07, Vol.45 (7), p.1812-1822 |
| issn | 1043-3074 1097-0347 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | multiple primary carcinomas non‐drinker non‐smoker Oral cancer Oral carcinoma Oral squamous cell carcinoma Smoking Squamous cell carcinoma survival Tongue |
| title | Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study |
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