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Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants
Objective To determine the clinical/echocardiography (ECHO) phenotype of patients with hypoxic respiratory failure (HRF) and response to late surfactant, according to patent ductus arteriosus (PDA) status. Study design This retrospective study included infants ≤26 +6 weeks gestation who received ≥1...
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| Published in: | Journal of perinatology 2023-10, Vol.43 (10), p.1245-1251 |
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| container_end_page | 1251 |
| container_issue | 10 |
| container_start_page | 1245 |
| container_title | Journal of perinatology |
| container_volume | 43 |
| creator | Beauchene, Madeline S. Cunningham, Alison M. Stanford, Amy H. Bischoff, Adrianne R. Dagle, John M. Rios, Danielle R. Klein, Jonathan M. Giesinger, Regan E. McNamara, Patrick J. |
| description | Objective
To determine the clinical/echocardiography (ECHO) phenotype of patients with hypoxic respiratory failure (HRF) and response to late surfactant, according to patent ductus arteriosus (PDA) status.
Study design
This retrospective study included infants ≤26
+6
weeks gestation who received ≥1 surfactant dose after 6 postnatal days and where PDA status was available by ECHO. Response to surfactant was appraised based on change in respiratory severity score over 48 h. The relationship between PDA status and response to surfactant was evaluated via univariate analysis.
Result
We studied late surfactant (
n
= 71 doses) administration in 35 preterm infants born at a mean weight and GA at birth were 595 g (508, 696) and 23.3 (22.7, 25) weeks, respectively of whom 16 (46%) had a diagnosis of PDA. Positive response to late surfactant treatment was independently associated with absence of PDA [OR 26 (2, 334),
p
= 0.01] whereas presence of PDA was independently associated with negative response [OR 12 (1.1, 126),
p
= 0.04].
Conclusions
In neonates ≤26
+6
weeks gestation, with HRF, response to surfactant after postnatal day 6 is influenced by PDA status. Future trials should consider PDA status which may enhance diagnostic precision and refine patient selection for late surfactant treatment. |
| doi_str_mv | 10.1038/s41372-023-01689-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2811940882</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2811940882</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-d7c088739aadba6da590417f3ef37cf549a439c64d1c6aefaf30e5e0573b09933</originalsourceid><addsrcrecordid>eNp9kD1PwzAURS0EouXjDzCgSCxlCNixE8djVT6lSnSAEVmvzjNq1STFdgb-PQ4pIDEw2dY97z7rEHLG6BWjvLz2gnGZpTTjKWVFqdJsj4yZkEWa54LvkzGVgqclF8WIHHm_prQP5SEZcckKqmQxJq8LCNiEpOpM6HwCLqBbtT5eJ4ub6WUCTZU49Nu28ZiENtlEPPGds2ACxLngEELdN6yaZOuwhtA5jA8bU39CDixsPJ7uzmPycnf7PHtI50_3j7PpPDWCqZBW0tCylFwBVEsoKsgVFUxajpZLY3OhQHBlClExUwBasJxijjSXfEmV4vyYTIberWvfO_RB1ytvcLOBBtvO66xkTIm4I4voxR903Xauib-LlKSsjFpYpLKBMq713qHVW7eqwX1oRnUvXw_ydZSvv-Trvvp8V90ta6x-Rr5tR4APgI9R84bud_c_tZ8sGI-w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2870189761</pqid></control><display><type>article</type><title>Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants</title><source>Nexis UK</source><source>Springer Nature</source><creator>Beauchene, Madeline S. ; Cunningham, Alison M. ; Stanford, Amy H. ; Bischoff, Adrianne R. ; Dagle, John M. ; Rios, Danielle R. ; Klein, Jonathan M. ; Giesinger, Regan E. ; McNamara, Patrick J.</creator><creatorcontrib>Beauchene, Madeline S. ; Cunningham, Alison M. ; Stanford, Amy H. ; Bischoff, Adrianne R. ; Dagle, John M. ; Rios, Danielle R. ; Klein, Jonathan M. ; Giesinger, Regan E. ; McNamara, Patrick J.</creatorcontrib><description>Objective
To determine the clinical/echocardiography (ECHO) phenotype of patients with hypoxic respiratory failure (HRF) and response to late surfactant, according to patent ductus arteriosus (PDA) status.
Study design
This retrospective study included infants ≤26
+6
weeks gestation who received ≥1 surfactant dose after 6 postnatal days and where PDA status was available by ECHO. Response to surfactant was appraised based on change in respiratory severity score over 48 h. The relationship between PDA status and response to surfactant was evaluated via univariate analysis.
Result
We studied late surfactant (
n
= 71 doses) administration in 35 preterm infants born at a mean weight and GA at birth were 595 g (508, 696) and 23.3 (22.7, 25) weeks, respectively of whom 16 (46%) had a diagnosis of PDA. Positive response to late surfactant treatment was independently associated with absence of PDA [OR 26 (2, 334),
p
= 0.01] whereas presence of PDA was independently associated with negative response [OR 12 (1.1, 126),
p
= 0.04].
Conclusions
In neonates ≤26
+6
weeks gestation, with HRF, response to surfactant after postnatal day 6 is influenced by PDA status. Future trials should consider PDA status which may enhance diagnostic precision and refine patient selection for late surfactant treatment.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-023-01689-2</identifier><identifier>PMID: 37160976</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/443/592/75/593 ; 692/699/75 ; Cardiovascular disease ; Clinical outcomes ; Clinical trials ; Congenital diseases ; Coronary vessels ; Echocardiography ; Gestation ; Hypoxia ; Infants ; Medicine ; Medicine & Public Health ; Neonates ; Patients ; Pediatric Surgery ; Pediatrics ; Phenotypes ; Premature babies ; Premature birth ; Surfactants</subject><ispartof>Journal of perinatology, 2023-10, Vol.43 (10), p.1245-1251</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-d7c088739aadba6da590417f3ef37cf549a439c64d1c6aefaf30e5e0573b09933</citedby><cites>FETCH-LOGICAL-c419t-d7c088739aadba6da590417f3ef37cf549a439c64d1c6aefaf30e5e0573b09933</cites><orcidid>0000-0002-6693-1823 ; 0000-0002-6227-6761 ; 0000-0001-7648-8872 ; 0000-0002-2766-9244 ; 0000-0003-0015-466X ; 0000-0001-9218-1301</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37160976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beauchene, Madeline S.</creatorcontrib><creatorcontrib>Cunningham, Alison M.</creatorcontrib><creatorcontrib>Stanford, Amy H.</creatorcontrib><creatorcontrib>Bischoff, Adrianne R.</creatorcontrib><creatorcontrib>Dagle, John M.</creatorcontrib><creatorcontrib>Rios, Danielle R.</creatorcontrib><creatorcontrib>Klein, Jonathan M.</creatorcontrib><creatorcontrib>Giesinger, Regan E.</creatorcontrib><creatorcontrib>McNamara, Patrick J.</creatorcontrib><title>Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To determine the clinical/echocardiography (ECHO) phenotype of patients with hypoxic respiratory failure (HRF) and response to late surfactant, according to patent ductus arteriosus (PDA) status.
Study design
This retrospective study included infants ≤26
+6
weeks gestation who received ≥1 surfactant dose after 6 postnatal days and where PDA status was available by ECHO. Response to surfactant was appraised based on change in respiratory severity score over 48 h. The relationship between PDA status and response to surfactant was evaluated via univariate analysis.
Result
We studied late surfactant (
n
= 71 doses) administration in 35 preterm infants born at a mean weight and GA at birth were 595 g (508, 696) and 23.3 (22.7, 25) weeks, respectively of whom 16 (46%) had a diagnosis of PDA. Positive response to late surfactant treatment was independently associated with absence of PDA [OR 26 (2, 334),
p
= 0.01] whereas presence of PDA was independently associated with negative response [OR 12 (1.1, 126),
p
= 0.04].
Conclusions
In neonates ≤26
+6
weeks gestation, with HRF, response to surfactant after postnatal day 6 is influenced by PDA status. Future trials should consider PDA status which may enhance diagnostic precision and refine patient selection for late surfactant treatment.</description><subject>631/443/592/75/593</subject><subject>692/699/75</subject><subject>Cardiovascular disease</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Congenital diseases</subject><subject>Coronary vessels</subject><subject>Echocardiography</subject><subject>Gestation</subject><subject>Hypoxia</subject><subject>Infants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Patients</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Phenotypes</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Surfactants</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAURS0EouXjDzCgSCxlCNixE8djVT6lSnSAEVmvzjNq1STFdgb-PQ4pIDEw2dY97z7rEHLG6BWjvLz2gnGZpTTjKWVFqdJsj4yZkEWa54LvkzGVgqclF8WIHHm_prQP5SEZcckKqmQxJq8LCNiEpOpM6HwCLqBbtT5eJ4ub6WUCTZU49Nu28ZiENtlEPPGds2ACxLngEELdN6yaZOuwhtA5jA8bU39CDixsPJ7uzmPycnf7PHtI50_3j7PpPDWCqZBW0tCylFwBVEsoKsgVFUxajpZLY3OhQHBlClExUwBasJxijjSXfEmV4vyYTIberWvfO_RB1ytvcLOBBtvO66xkTIm4I4voxR903Xauib-LlKSsjFpYpLKBMq713qHVW7eqwX1oRnUvXw_ydZSvv-Trvvp8V90ta6x-Rr5tR4APgI9R84bud_c_tZ8sGI-w</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Beauchene, Madeline S.</creator><creator>Cunningham, Alison M.</creator><creator>Stanford, Amy H.</creator><creator>Bischoff, Adrianne R.</creator><creator>Dagle, John M.</creator><creator>Rios, Danielle R.</creator><creator>Klein, Jonathan M.</creator><creator>Giesinger, Regan E.</creator><creator>McNamara, Patrick J.</creator><general>Nature Publishing Group US</general><general>Nature Publishing 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ductus arteriosus (PDA) and response to late surfactant treatment in premature infants</title><author>Beauchene, Madeline S. ; Cunningham, Alison M. ; Stanford, Amy H. ; Bischoff, Adrianne R. ; Dagle, John M. ; Rios, Danielle R. ; Klein, Jonathan M. ; Giesinger, Regan E. ; McNamara, Patrick J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-d7c088739aadba6da590417f3ef37cf549a439c64d1c6aefaf30e5e0573b09933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>631/443/592/75/593</topic><topic>692/699/75</topic><topic>Cardiovascular disease</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Congenital diseases</topic><topic>Coronary vessels</topic><topic>Echocardiography</topic><topic>Gestation</topic><topic>Hypoxia</topic><topic>Infants</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Patients</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Phenotypes</topic><topic>Premature babies</topic><topic>Premature birth</topic><topic>Surfactants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beauchene, Madeline S.</creatorcontrib><creatorcontrib>Cunningham, Alison M.</creatorcontrib><creatorcontrib>Stanford, Amy H.</creatorcontrib><creatorcontrib>Bischoff, Adrianne R.</creatorcontrib><creatorcontrib>Dagle, John M.</creatorcontrib><creatorcontrib>Rios, Danielle R.</creatorcontrib><creatorcontrib>Klein, Jonathan M.</creatorcontrib><creatorcontrib>Giesinger, Regan E.</creatorcontrib><creatorcontrib>McNamara, Patrick J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology 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(Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beauchene, Madeline S.</au><au>Cunningham, Alison M.</au><au>Stanford, Amy H.</au><au>Bischoff, Adrianne R.</au><au>Dagle, John M.</au><au>Rios, Danielle R.</au><au>Klein, Jonathan M.</au><au>Giesinger, Regan E.</au><au>McNamara, Patrick J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>43</volume><issue>10</issue><spage>1245</spage><epage>1251</epage><pages>1245-1251</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective
To determine the clinical/echocardiography (ECHO) phenotype of patients with hypoxic respiratory failure (HRF) and response to late surfactant, according to patent ductus arteriosus (PDA) status.
Study design
This retrospective study included infants ≤26
+6
weeks gestation who received ≥1 surfactant dose after 6 postnatal days and where PDA status was available by ECHO. Response to surfactant was appraised based on change in respiratory severity score over 48 h. The relationship between PDA status and response to surfactant was evaluated via univariate analysis.
Result
We studied late surfactant (
n
= 71 doses) administration in 35 preterm infants born at a mean weight and GA at birth were 595 g (508, 696) and 23.3 (22.7, 25) weeks, respectively of whom 16 (46%) had a diagnosis of PDA. Positive response to late surfactant treatment was independently associated with absence of PDA [OR 26 (2, 334),
p
= 0.01] whereas presence of PDA was independently associated with negative response [OR 12 (1.1, 126),
p
= 0.04].
Conclusions
In neonates ≤26
+6
weeks gestation, with HRF, response to surfactant after postnatal day 6 is influenced by PDA status. Future trials should consider PDA status which may enhance diagnostic precision and refine patient selection for late surfactant treatment.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>37160976</pmid><doi>10.1038/s41372-023-01689-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6693-1823</orcidid><orcidid>https://orcid.org/0000-0002-6227-6761</orcidid><orcidid>https://orcid.org/0000-0001-7648-8872</orcidid><orcidid>https://orcid.org/0000-0002-2766-9244</orcidid><orcidid>https://orcid.org/0000-0003-0015-466X</orcidid><orcidid>https://orcid.org/0000-0001-9218-1301</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2023-10, Vol.43 (10), p.1245-1251 |
| issn | 0743-8346 1476-5543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2811940882 |
| source | Nexis UK; Springer Nature |
| subjects | 631/443/592/75/593 692/699/75 Cardiovascular disease Clinical outcomes Clinical trials Congenital diseases Coronary vessels Echocardiography Gestation Hypoxia Infants Medicine Medicine & Public Health Neonates Patients Pediatric Surgery Pediatrics Phenotypes Premature babies Premature birth Surfactants |
| title | Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants |
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