Aged black garlic (Allium sativum L.) and aged black elephant garlic (Allium ampeloprasum L.) alleviate obesity and attenuate obesity-induced muscle atrophy in diet-induced obese C57BL/6 mice

Garlic (Allium sativum L.) is a primary dietary component worldwide because of its health benefits and use as a traditional medicine. Elephant garlic (Allium ampeloprasum L.), a related species in the same genus, is less intense and sweeter than A. sativum. The object of this study was to investigat...

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Published in:Biomedicine & pharmacotherapy 2023-07, Vol.163, p.114810-114810, Article 114810
Main Authors: Chae, Jongbeom, Lee, Eunbi, Oh, Seon Min, Ryu, Hyung Won, Kim, Soorin, Nam, Ju-Ock
Format: Article
Language:English
Subjects:
Allium - chemistry
Animals
Antioxidants - pharmacology
Black garlic
Diet
Elephant garlic
Garlic - chemistry
Mice
Mice, Inbred C57BL
Muscle differentiation
Muscular Atrophy - drug therapy
Muscular Atrophy - etiology
Muscular Atrophy - prevention & control
Obesity - complications
Obesity - drug therapy
Onions
Sarcopenic obesity
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Summary:Garlic (Allium sativum L.) is a primary dietary component worldwide because of its health benefits and use as a traditional medicine. Elephant garlic (Allium ampeloprasum L.), a related species in the same genus, is less intense and sweeter than A. sativum. The object of this study was to investigate the alleviative effects of aged black garlic (ABG) and aged black elephant garlic (ABEG) on obesity and muscle atrophy induced by obesity in high fat diet-induced obese mice. We demonstrated that ABG and ABEG alleviated obesity and muscle atrophy and enhanced myogenic differentiation and myotube hypertrophy, and this effect was mediated by the upregulation of Akt/mTOR/p70S6K signaling. Furthermore, a candidate bioactive compound of ABG and ABEG was suggested in this study through analysis using gas chromatography-mass spectroscopy and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectroscopy. In conclusion, ABG and ABEG may alleviate obesity and treat obesity-induced muscle atrophy. [Display omitted] •Aged black garlic extract and aged black elephant garlic alleviate obesity in high fat diet induced obese C57BL/6 mice.•ABG and ABEG attenuate sarcopenic obesity and enhance myogenic differentiation or hypertrophy via Akt/mTOR/p70S6K signaling.•S-methyl-L-cysteine and L-proline were selected as candidate bioactive compounds of ABG and ABEG.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2023.114810