Magnetic Resonance–Guided focused ultrasound surgery for Parkinson's disease: A mini-review and comparison between deep brain stimulation

Magnetic resonance–guided focused ultrasound (MRgFUS) is a new surgical treatment for Parkinson's disease (PD). Previous experience with radiofrequency lesionectomy and deep brain stimulation (DBS) has identified several candidate targets for MRgFUS intended to alleviate the motor symptoms of P...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2023-06, Vol.111, p.105431-105431, Article 105431
Main Authors: Ko, Tzu-Hsiang, Lee, Yu-Hsuan, Chan, Lung, Tsai, Kevin Wen-Kai, Hong, Chien-Tai, Lo, Wei-Lun
Format: Article
Language:English
Subjects:
Deep Brain Stimulation
Essential Tremor - therapy
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Magnetic resonance–guided focused ultrasound surgery
Parkinson Disease - diagnostic imaging
Parkinson Disease - surgery
Parkinson's disease
Treatment Outcome
Ultrasonic Surgical Procedures
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Summary:Magnetic resonance–guided focused ultrasound (MRgFUS) is a new surgical treatment for Parkinson's disease (PD). Previous experience with radiofrequency lesionectomy and deep brain stimulation (DBS) has identified several candidate targets for MRgFUS intended to alleviate the motor symptoms of PD. The main advantage of MRgFUS is that it is incisionless. MRgFUS has certain limitations and is associated with adverse effects. The present study reviews the literature on conventional surgical interventions for PD, discusses recent studies on MRgFUS, and the comparison between DBS and MRgFUS for PD. The reviews aims to provide an essential reference for neurologists to select the appropriate treatments for patients with PD. •Magnetic resonance–guided focused ultrasound (MRgFUS) is a new surgical treatment for Parkinson’s disease (PD).•The majority targets of MRgFUS for PD are thalamus, subthalamic nucleus, globus pallidus interna and pallidothalamic tract.•The main advantages of MRgFUS are the incisionless, real-time monitoring and no general anaesthesia or implantation.•The disadvantages of MRgFUS are the skull characteristics, unilaterality, non-adjustable and relevant adverse effects.•Comparing with deep brain stimulation, limited studies, few patients and long-term benefit uncertainties are concerned.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2023.105431