Study on sentinel symptoms and influencing factors of postoperative chemotherapy in patients with gastric cancer

• Published in: European journal of oncology nursing : the official journal of European Oncology Nursing Society 2023-06, Vol.64, p.102318-102318, Article 102318
• Main Authors: Wei, Lanzhi, Lv, Fei, Luo, Caifeng, Fang, Yan
• Format: Article
• Language: English
• Subjects: Apriori algorithm; Chemotherapy; Cross-Sectional Studies; Fatigue - etiology; Gastric cancer; Humans; Nausea; Sentinel symptom; Stomach Neoplasms - drug therapy; Stomach Neoplasms - surgery; Symptom cluster; Syndrome
• ISSN: 1462-3889; 1532-2122
• DOI: 10.1016/j.ejon.2023.102318

To explore the symptom clusters of gastric cancer patients receiving postoperative chemotherapy, identify the sentinel symptom of each symptom cluster, and compare the differences in sentinel symptoms of patients for gastric cancer with different characteristics. This was a cross-sectional study. Patients with postoperative gastric cancer who received chemotherapy in the medical oncology department from October 2021 to July 2022 were selected for the study using a convenience sampling method.The General Information Questionnaire and the MD Anderson Symptom Inventory Gastrointestinal Cancer (MDASI-GI) were used for the survey. A total of 245 patients participated in the study. There were five symptom clusters in the patients. Fatigue, nausea, sadness, and taste alteration were the sentinel symptoms of the disease symptom cluster, gastrointestinal symptom cluster, emotional symptom cluster, and neurotoxic symptom cluster, respectively. No clear sentinel symptom was found in the gastric-cancer-specific symptom cluster. Statistically significant differences were observed in fatigue, nausea, sadness, and taste alteration among patients receiving postoperative chemotherapy for gastric cancer with differences in gender, duration since diagnosis, tumor site, chemotherapy regimen, chemotherapy cycle, red blood cell count, hemoglobin level, albumin level, plasma D-dimer level, indirect bilirubin level, glutamic pyruvic transaminase level, total bile acid level, and uric acid level. People with postoperative chemotherapy for gastric cancer experience multiple concurrent symptoms. Of the multiple symptoms that occur simultaneously, patients tend to focus on 1 or 2 symptoms of particular significance and use the occurrence of 1 symptom to explain the others. The understanding of symptom clusters and sentinel symptoms could be beneficial to assess and manage both in postoperative patients with gastric cancer during chemotherapy. Clinical staff should use sentinel symptoms as the targets for symptom cluster evaluation and effective intervention. •Sentinel symptom is defined as an indicator of an symptom cluster (SC), and can help to predict the occurrence of other symptoms within the SC.•Fatigue, nausea, sadness, and taste alteration were the sentinel symptoms of the disease SC, gastrointestinal SC, emotional SC, and neurotoxic SC, respectively. No clear sentinel symptom was found in the gastric-cancer-specific SC.•Statistically significant differences were observed in f