Pneumococcal vaccination status among cirrhotic patients in Italy: a neglected topic

To date, few reports have evaluated the pneumococcal vaccination status in cirrhotic patients. No data are available for European countries. We have explored this topic and the potential independent predictors motivating lack of vaccination in Italy. Between January 1 st and June 30 th 2022, 1419 ci...

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Published in:European journal of clinical microbiology & infectious diseases 2023-08, Vol.42 (8), p.945-950
Main Authors: Stroffolini, Tommaso, Ciancio, Alessia, Federico, Alessandro, Benigno, Rosa G., Colloredo, Guido, Lombardi, Anna, Cotugno, Rosa, Verucchi, Gabriella, Ferrigno, Luigina, Gioli, Federico, Marignani, Massimo, Troshina, Yulia, Romeo, Mario, Di Costanzo, Francesco, Niro, Grazia Anna, Badia, Lorenzo
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Chronic infection
Etiology
Immunization
Internal Medicine
Liver cirrhosis
Liver diseases
Medical Microbiology
Original Article
Pneumonia
Regression analysis
Streptococcus infections
Vaccines
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Summary:To date, few reports have evaluated the pneumococcal vaccination status in cirrhotic patients. No data are available for European countries. We have explored this topic and the potential independent predictors motivating lack of vaccination in Italy. Between January 1 st and June 30 th 2022, 1419 cirrhotic patients of any etiology were consecutively enrolled in an observational, prospective study at 8 referral centers in Italy. Adjusted odds ratios (ORs) for the association with lack of vaccination were evaluated by multiple logistic regression analysis. Overall vaccine coverage was 17.9% (8.9% in patients < 65 years of age and 27.1% in those aged ≥ 65 years; p < 0.001). Among the 1165 unvaccinated patients, 1068 (91.7%) reported lack of information regarding vaccination as the reason for not having undergone vaccination. Independent predictors associated with lack of vaccination were age < 65 years (OR 3.39, CI 95% 2.41–4.76) and a higher number of schooling years (OR 2.14, CI 95% 1.58–2.91); alcoholic etiology resulted only marginally associated (OR 1.91, CI 95% 1.03–3.52). These findings establish evidence on how pneumococcal vaccination status in Italy is largely suboptimal among cirrhotic patients. These results raise concern, considering the severe outcomes of pneumococcal infection in patients with chronic liver diseases.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-023-04614-9