Jointly Depleting Glutathione Based on Self‐Assembled Nanomicelles for Enhancing Photodynamic Therapy

Photodynamic therapy (PDT) is one common ROS‐generating therapeutic method with high tumor selectivity and low side effects. But the GSH‐upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by pre...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2023-08, Vol.24 (16), p.e202300323-n/a
Main Authors: Wu, Jingxi, Shang, Jingjing, An, Jing, Chen, Wenlong, Hong, Gaobo, Hou, Haoran, Zheng, Wen‐Heng, Song, Fengling, Peng, Xiaojun
Format: Article
Language:English
Subjects:
Activatable photosensitizer
Curcumin
Depletion
Glutathione
Nanomicelles
Photodynamic therapy
Polymers
Self-assembly
Side effects
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Summary:Photodynamic therapy (PDT) is one common ROS‐generating therapeutic method with high tumor selectivity and low side effects. But the GSH‐upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self‐assembly method from GSH‐activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS. A new strategy of jointly depleting GSH is proposed to enhance the therapeutic effect of PDT by preparing a nanomicelle by self‐assembly method from GSH‐activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202300323