Expression of p16 Tumor Suppressor Protein in Malignant Ovarian Germ Cell Tumors; Immunohistochemical Study

Background Malignant ovarian germ cell tumors represent small percentage of malignant ovarian neoplasms but they affect significantly young age group. Aim of the study To investigate the immunohistochemical expression of p16 tumor suppressor protein in malignant ovarian germ cell tumors. Materials a...

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Bibliographic Details
Published in:International journal of surgical pathology 2024-02, Vol.32 (1), p.66-74
Main Authors: Hosny, Ghada, Ahmed, Omar A, Ahmed, Rania Makboul, Fadel, Sabah Ahmed
Format: Article
Language:English
Subjects:
Kinases
Ovaries
Proteins
Tumors
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Summary:Background Malignant ovarian germ cell tumors represent small percentage of malignant ovarian neoplasms but they affect significantly young age group. Aim of the study To investigate the immunohistochemical expression of p16 tumor suppressor protein in malignant ovarian germ cell tumors. Materials and Methods Twenty-two malignant ovarian germ cell tumors (five dysgerminoma, eight immature teratoma, and nine yolk sac tumors), twenty mature cystic teratoma tumors and twenty normal ovarian tissue were immunohistochemically stained with p16 monoclonal antibody. Ki67 immunohistochemical staining was done for malignant ovarian germ cell tumors to assess proliferation. Results We found that p16 tumor suppressor protein is overexpressed in all malignant ovarian germ cell tumors in both nuclear and cytoplasmic locations compared to control and to mature cystic teratoma (p-value
ISSN:1066-8969
1940-2465
DOI:10.1177/10668969231168358